Modulation of the Respiratory Burst by Naturally Occurring Substances

  • Stanley D. Somerfield
  • Emil Skamene


The respiratory burst and subsequent production of oxygen radicals and metabolites by the leukocyte are considered important contributing processes in nonspecific microbicidal systems.1 In addition, in disease states in which inflammation, tissue destruction, and the apparent absence of bacterial invasion are predominant features, excessive and inappropriate production of oxygen radicals and metabolites is thought to play a substantial role in continuing tissue destruction.2 Despite a lack of substantial direct evidence for a primary role, there is nonetheless much indirect evidence incriminating oxygen metabolites as playing a major contributing role in inflammation.2 Oxygen radicals have been strongly implicated as pathogenic in a wide variety of inflammatory disease states involving most physiological organ systems.3


Vasoactive Intestinal Peptide Platelet Activate Factor Human Neutrophil Respiratory Burst Human Polymorphonuclear Leukocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Stanley D. Somerfield
    • 1
  • Emil Skamene
    • 1
  1. 1.Division of Clinical Immunology and AllergyThe Montreal General HospitalMontrealCanada

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