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The Respiratory Burst and Lymphocyte Function

  • Arthur L. SagoneJr.

Abstract

Recent studies have established that phagocytic cells generate several reactive oxygen species (ROS).1–24 Normally, under resting or baseline conditions, unstimulated granulocytes and monocytes appear to release only minimal, and probably nontoxic, amounts of ROS. However, during an immunological response, phagocytic cells may have a burst in oxidative metabolism (a respiratory burst), resulting in an enhanced release of ROS at an inflammatory site.25–27 Since lymphocytes are an essential part of the inflammatory response, the potent compounds released by phagocytic cells might modify the functional capacity of these cells. This chapter discusses the possible effects of the ROS produced by phagocytic cells during the respiratory burst on the functional capacity of human lymphocytes at a site of inflammation.

Keywords

Oxidative Metabolism Human Lymphocyte Phorbol Myristate Acetate Respiratory Burst Chronic Granulomatous Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Arthur L. SagoneJr.
    • 1
  1. 1.Department of Medicine and Pharmacology, Division of Hematology and OncologyOhio State University, College of MedicineColumbusUSA

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