The Respiratory Burst and Endothelial Cells

  • Aldo Dobrina
  • Pierluigi Patriarca


Neutrophils are the first-line defense of the host against foreign invaders once they have reached the tissues. When at work, however, the neutrophils behave as a double-edged sword. In fact, the reactive oxygen intermediates (ROI) generated by the respiratory burst and the granular components released during degranulation contribute to killing of ingested microorganisms on one side, but, on the other they may damage tissues in both their cellular and extracellular components. Several cell types, including the neutrophils themselves, may be the target of ROI produced by the neutrophil respiratory burst.1 Endothelial cells, a crucial cell type in the interface phenomena between blood and tissues, are among those targets. This chapter first reviews evidence, from both in vitro and in vivo studies, of the involvement of the neutrophil respiratory burst in endothelial cell damage, followed by a discussion of the possible role of such a damage in human pathology.


Endothelial Cell Phorbol Myristate Acetate Respiratory Burst Chronic Granulomatous Disease Neutrophil Elastase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Aldo Dobrina
    • 1
  • Pierluigi Patriarca
    • 1
  1. 1.Institute of General PathologyUniversity of TriesteTriesteItaly

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