The Respiratory Burst and Cellular Ion Homeostasis

  • Barbara Styrt
  • Mark S. Klempner


The respiratory burst of phagocytic cells uses electron transfer to produce a series of highly reactive toxic oxygen metabolites. This process is accompanied by a complex pattern of ion redistribution between the cell and its environment and among subcellular compartments. The relationships between ion fluxes and the respiratory burst have been under intensive investigation in recent years, spurred by the rapidly progressing elucidation of the NADPH oxidase complex responsible for the burst and by the introduction of several fluorescent indicators facilitating the study of intracellular ion transients.


NADPH Oxidase Human Neutrophil Respiratory Burst Chronic Granulomatous Disease Pertussis Toxin 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Barbara Styrt
    • 1
  • Mark S. Klempner
    • 2
  1. 1.Department of MedicineMichigan State UniversityEast LansingUSA
  2. 2.Department of MedicineTufts-New England Medical CenterBostonUSA

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