The Respiratory Burst and the NADPH Oxidase of Phagocytic Leukocytes

  • Dirk Roos
  • René Lutter
  • Ben G. J. M. Bolscher


When phagocytic leukocytes are activated to kill microorganisms, these cells respond with considerable changes in their cellular metabolism and structure.1 Most marked is a 20- to 30-fold increase in the oxygen consumption (i.e., the respiratory burst) that is not sensitive to inhibitors of the mitochondrial respiration.2 The extra oxygen consumption reflects the action of a phagocyte-specific oxidase, responsible for the generation of reduced oxygen species.1 This enzyme is localized in the plasma membrane and—after phagocytosis—in the phagosomal membranes of the cell.3,4


NADPH Oxidase Oxidase Activity Human Neutrophil Respiratory Burst Chronic Granulomatous Disease 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Dirk Roos
    • 1
  • René Lutter
    • 1
  • Ben G. J. M. Bolscher
    • 1
  1. 1.Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory of Experimental and Clinical ImmunologyUniversity of AmsterdamAmsterdamThe Netherlands

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