The Respiratory Burst and Aging

  • Tamás FülöpJr.
  • Gabriella Fóris
  • József T. Nagy
  • Zsuzsa Varga
  • András Leövey


When exposed to certain stimuli, phagocytic cells (neutrophils and mononuclear phagocytes) undergo marked changes in the way they handle oxygen.1 Their rates of oxygen uptake increase greatly, they begin to produce large amounts of superoxide (O 2 ) and hydrogen peroxide (H2O2), and they begin to metabolize large quantities of glucose by way of the hexose monophosphate shunt. Because of the sharp increase in oxygen uptake, this series of changes has come to be known as the respiratory burst. Its purpose is to generate powerful microbicidal agents by the partial reduction of oxygen.


Human Neutrophil Phorbol Myristate Acetate Respiratory Burst Phagocytic Cell Phorbol Myristate Acetate 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Tamás FülöpJr.
    • 1
  • Gabriella Fóris
    • 1
  • József T. Nagy
    • 1
  • Zsuzsa Varga
    • 1
  • András Leövey
    • 1
  1. 1.First Department of MedicineUniversity Medical SchoolDebrecenHungary

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