The Respiratory Burst and Atherosclerosis

  • George Paragh
  • Éva M. Kovács
  • József T. Nagy
  • Gabriella Foŕis
  • Tamás FülöpJr.


The tissue-damaging effect of free radicals generated by the respiratory burst is frequently discussed in the literature.1–5 It is also mentioned in review articles that the reactive oxygen species (ROS) produced by mononuclear and polymorphonuclear phagocytes (PMN) may contribute to injury to the vessel wall, especially in the endothelial cell (EC), in different types of vasculitis, and in the vessels of inflamed regions.3 But up to the present, the role of ROS generation by monocytes and granulocytes in the development of generalized atherosclerosis has not been taken into serious consideration.


Reactive Oxygen Species Generation Respiratory Burst Pertussis Toxin Foam Cell Formation Arterial Smooth Muscle Cell 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • George Paragh
    • 1
  • Éva M. Kovács
    • 1
  • József T. Nagy
    • 1
  • Gabriella Foŕis
    • 1
  • Tamás FülöpJr.
    • 1
  1. 1.First Department of MedicineUniversity Medical SchoolDebrecenHungary

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