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The Respiratory Burst and Mechanisms of Oxygen Radical-Mediated Tissue Injury

  • Jeffrey S. Warren
  • Peter A. Ward
  • Kent J. Johnson

Abstract

Although it has been recognized since the nineteenth century that the influx of phagocytic cells into sites of tissue injury is critical to the development of the inflammatory response, the recognition that neutrophils, monocytes, and macrophages are complex cells possessing diverse biological capabilities is relatively recent. Inflammatory cells are controlled by an extensive array of biochemical mediators. The concept that leukocytic proteases contribute to the tissue injury observed in acute inflammation has considerable supporting evidence but has been extensively broadened in recent years.1,2 Although numerous studies have demonstrated that lysosomal proteases can cause or enhance tissue injury, other studies have shown that tissue injury cannot be completely prevented by antiproteases.3,4 In addition, tissue injury still occurs in strains of mice whose leukocytes are deficient of proteases suggesting that other mechanisms are important in phagocyte-mediated tissue injury.5 Recent studies have provided compelling evidence that leukocyte-derived oxygen radicals and their metabolites are important mediators of inflammation and tissue injury.

Keywords

Lung Injury Acute Lung Injury Phorbol Myristate Acetate Endothelial Cell Injury Human Neutrophil Elastase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jeffrey S. Warren
    • 1
  • Peter A. Ward
    • 1
  • Kent J. Johnson
    • 1
  1. 1.Department of PathologyUniversity of Michigan Medical SchoolAnn ArborUSA

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