The Respiratory Burst and the Metabolism of Drugs

  • Arthur L. SagoneJr.


It has only been about 20 years since it was first demonstrated that the granulocytes of patients with chronic granulomatous disease (CGD) lack a burst in oxidative metabolism.1 This observation stimulated extensive study of this aspect of granulocyte physiology and has established the importance of reactive oxygen species (ROS) in the functional capacity of phagocytic cells.2–6 The complex nature of this biochemical pathway as well as an ever-expanding role of ROS in diverse physiological processes is becoming more apparent with each new report. In addition, there is now evidence that these oxygen metabolites may be major mediators of the inflammatory process occurring in patients with several diverse clinical disorders.7–25


Salicylic Acid Benzoic Acid Human Neutrophil Chronic Granulomatous Disease Phagocytic Cell 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Arthur L. SagoneJr.
    • 1
  1. 1.Department of Medicine and Pharmacology, Division of Hematology and OncologyOhio State University, College of MedicineColumbusUSA

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