Cachectin (Tumor Necrosis Factor)

A Macrophage Protein that Induces a Catabolic State and Septic Shock in Infected Animals
  • Kirk R. Manogue
  • Anthony Cerami
Part of the New Horizons in Therapeutics book series (NHTH)


Invasive stimuli, including parasitic, bacterial, or viral infection and neoplastic disease, precipitate catabolic changes in cellular metabolism and pathological alterations in the physiology of their mammalian hosts. These disruptions of normal homeostasis, left unresolved, can lead to the depletion of host energy stores advancing to wasting (cachexia), tissue damage, multiple organ system failure, shock, and death. Although such symptomatic patterns are all too familiar to clinicians, the underlying causes of this progressive decline have remained obscure. Because these patterns are frequently attributed to the metabolic demands or direct actions of the pathogen or its products, treatment has quite naturally focused on aggressive elimination of the invading agent and reactive support of failing host physiology. It now appears that invasive stimuli provide a trigger for the release of host-secreted cytokines, and the combined actions of these endogenous mediators elicit most or all of the biologic responses culminating in the pathophysiology of cachexia and shock. This new appreciation for the essential role of host-derived inflammatory mediators has provided a focus for new therapeutic approaches to a broad spectrum of invasive diseases.


Tumor Necrosis Factor Visceral Leishmaniasis Procoagulant Activity Trypanosoma Brucei Peritoneal Exudate Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Kirk R. Manogue
    • 1
  • Anthony Cerami
    • 1
  1. 1.Laboratory of Medical BiochemistryThe Rockefeller UniversityNew YorkUSA

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