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Interleukin-1

Biology and Molecular Biology

  • Chapter
Cellular and Molecular Aspects of Inflammation

Part of the book series: New Horizons in Therapeutics ((NHTH))

Abstract

Interleukin-1 (IL-1) was originally described as a macrophage-derived low molecular weight (13–17 kd) polypeptide that acts as a comitogen with phytohemagglutinin (PHA) or concanavilin A (Con A) in cultures of murine thymocytes (Gery et al., 1972). Subsequent studies revealed that IL-1 was stimulatory for a broad range of T-cell-dependent in vitro immune responses including antibody synthesis (Koopman et al.,1978; Staruch and Wood, 1983), cytotoxic T cell activation (Farrar et al.,1980), and mitogen- and antigen-induced T cell proliferation (Gery et al.,1972; Mizel and Ben-Zvi, 1980; Mizel, 1982; Dinarello, 1984; Oppenheim et al.,1986). More recent studies indicate that IL-1 may also play an essential role in thymocyte maturation (DeLuca and Mizel, 1986). B cells, as well as T cells, have been characterized as IL-1 responsive. For example, IL-1 can induce the synthesis of kappa light chains and surface immunoglobulin expression in pre-B cells (Giri et al.,1984) and function as a comitogen in B cell proliferation (Howard et al.,1983). Within the last few years, it has become evident that the biologic activity of IL-1 is not restricted to lymphocytes. Indeed, this mediator can modify the growth and secretory activity of a large number of cell types, including fibroblasts, hepatocytes, endothelial cells, chondrocytes, natural killer cells, synovial cells, and osteoclasts (Dinarello, 1984; Oppenheim et al.,1986), which share a common involvement in immune or inflammatory responses. The overlapping responsiveness to IL-1 may provide one mechanism for the coordinated control of the diverse cell types that are involved in an immune or inflammatory response.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Wake Forest University Medical Center, Winston-Salem, North Carolina, 27103, USA

    Steven B. Mizel

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  1. Steven B. Mizel
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Editors and Affiliations

  1. Department of Molecular Pharmacology, Smith Kline & French Laboratories, 19101, Philadelphia, Pennsylvania, USA

    George Poste  & Stanley T. Crooke  & 

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© 1988 Plenum Press, New York

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Mizel, S.B. (1988). Interleukin-1. In: Poste, G., Crooke, S.T. (eds) Cellular and Molecular Aspects of Inflammation. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5487-1_6

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  • DOI: https://doi.org/10.1007/978-1-4684-5487-1_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5489-5

  • Online ISBN: 978-1-4684-5487-1

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