Peptide Mediators of Inflammation
Some of us who have been attempting to understand the mechanisms of inflammation have focused on the nature of the interactions among component cells in inflammatory lesions. The deleterious consequences of chronic inflammatory diseases result from the effects of these interactions on resident cells of the involved tissues (Krane et al., 1982). In most of these tissues, mesenchymal cells such as fibroblasts are the target cells, and monocytes and lymphocytes are the effector cells. It has become apparent, however, that the distinction between effector and target is blurred, since the so-called target cells can also profoundly influence functions of the effector cells. The interactions among these cells are mediated through direct cell contact or the release of soluble ligands that act by binding through specific cellular receptors.
KeywordsCollagen Synthesis Synovial Fibroblast Synovial Cell Articular Chondrocytes Human Mononuclear Cell
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- Dayer, J.-M., Goldring, S. R., Robinson, D. R., and Krane, S. M., 1979, Effects of human mononuclear cell factor on cultured rheumatoid synovial cells. Interactions of prostaglandin E2 and cyclic adenosine 3’, 5’-monophosphate, Biochim, Biophvs, Acta 586: 87–105.Google Scholar
- Dinarello, C. A., Cannon, J. G., Mier, J. W., Bernheim, H. A., LoPreste, G., Lynn, D. L., Love, R. N., Webb, A. C., Auron, P. E., Reuben, R. C., Rich, A., Wolff, S. M., and Putney, S. D., 1986, Multiple biological activities of human recombinant interleukin 1, J. Clin. Invest. 77: 1734–1739.PubMedCrossRefGoogle Scholar
- Goldring, M. B., and Krane, S. M., 1986, Modulation of collagen synthesis in human chondrocyte cultures by interleukin 1, J. Bone Mineral Res. 1 (Suppl. 1): 56 (Abstract).Google Scholar
- Goldring, S. R., Roelke, M. S., Petrison, K. K., and Krane, S. M., 1986, Interleukin 1 (IL 1) mediates effects of soluble monocyte—macrophage products on responses to prostaglandin E2 (PGE2); A potential mechanism for regulating cellular activity at sites of inflammation, J. Bone Mineral Res. 1 (Suppl. 1): 55Google Scholar
- Goldring, S. R., Roelke, M. S., Petrison, K. K., Evins, A. E., and Krane, S. M., 1987a, Mechanisms by which monocyte—macrophage products regulate responses of connective tissue (bone and synovial) cells to hormones, J. Bone Mineral Res. 2 (Suppl.1): 239 (Abstract).Google Scholar
- Goldring, M. B., Birkhead, J. R., Sandell, L. J., and Krane, S. M., 19876, Differential effects of recombinant interleukin 1 and phorbol ester on collagen synthesis and procollagen mRNA levels in cultured human chondrocytes, Arthritis Rheum. 30:(Suppl.):129 (Abstract).Google Scholar
- Krane, S. M., Goldring, S. R., and Dayer, J.-M., 1982, Interactions among lymphocytes, monocytes, and other synovial cells in the rheumatoid synovium, Lymphokines 7: 75–136.Google Scholar
- Krane, S. M., Dayer, J.-M., Simon, L. S., and Byrne, M. S., 1985, Mononuclear cell-conditioned medium containing mononuclear cell factor (MCF), homologous with interleukin I, stimulates collagen and fibronectin synthesis by adherent rheumatoid synovial cells: Effects of prostaglandin E, and indomethacin, Collagen Relat. Res. 5: 99–117.Google Scholar
- Rupp, E. A., Cameron, P. M., Ranawat, C. S., Schmidt, J. A., and Bayne, E. K., 1986, Specific bioactivities of monocyte-derived interleukin la and interleukin 1β are similar to each other on cultured murine thymocytes and on cultured human connective tissue cells, J. Clin. Invest. 78: 836–839.PubMedCrossRefGoogle Scholar
- Stephenson, M. L., Goldring, M. B., Birkhead, J. R., Krane, S. M., Rahmsdorf, H. J., and Angel, P., 1987, Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin I G3 or phorbol ester, Biochem. Biophys. Res. Commun. 144: 583–590.PubMedCrossRefGoogle Scholar