Some Novel Phospholipase C Activities

Actions on Phosphatidylcholine and on Phosphatidylinositol-Glycans as Anchors for Membrane Proteins and as Precursors for Possible Insulin Mediators
  • Pedro Cuatrecasas
Part of the New Horizons in Therapeutics book series (NHTH)


During the past few years, as illustrated by this and other recent volumes, there has been considerable interest in a hormone-sensitive phospholipase C that acts specifically on polyphosphoinositides. Upon receptor activation by certain agonists (e.g., adrenergic agonists, acetylcholine, serotonin, vasopressin, and platelet-derived growth factor), this membrane-localized enzyme(s) hydrolyzes primarily phosphatidylinositol 4, 5-bisphosphate into 1, 2-diacylglycerol and inositol-1,4,5-trisphosphate. These substances, which often act synergistically in certain biological systems, activate protein kinase C(s) and release calcium from intracellular stores, respectively. Many interesting complexities of this important regulatory system continue to evolve.


Bacillus Cereus Inositol Phosphate Variant Surface Glycoprotein Phosphatidylinositol Mannosides Membrane Precursor 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Pedro Cuatrecasas
    • 1
  1. 1.Glaxo Research LaboratoriesGlaxo, Inc.Research Triangle ParkUSA

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