Part of the
New Horizons in Therapeutics
book series (NHTH)
Some Novel Phospholipase C Activities
Actions on Phosphatidylcholine and on Phosphatidylinositol-Glycans as Anchors for Membrane Proteins and as Precursors for Possible Insulin Mediators
During the past few years, as illustrated by this and other recent volumes, there has been considerable interest in a hormone-sensitive phospholipase C that acts specifically on polyphosphoinositides. Upon receptor activation by certain agonists (e.g., adrenergic agonists, acetylcholine, serotonin, vasopressin, and platelet-derived growth factor), this membrane-localized enzyme(s) hydrolyzes primarily phosphatidylinositol 4, 5-bisphosphate into 1, 2-diacylglycerol and inositol-1,4,5-trisphosphate. These substances, which often act synergistically in certain biological systems, activate protein kinase C(s) and release calcium from intracellular stores, respectively. Many interesting complexities of this important regulatory system continue to evolve.
KeywordsBacillus Cereus Inositol Phosphate Variant Surface Glycoprotein Phosphatidylinositol Mannosides Membrane Precursor
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© Plenum Press, New York 1988