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LTD4 Receptors and Signal Transduction Processes

  • Stanley T. Crooke
  • Seymour Mong
  • Mike Clark
  • Henry Sarau
  • Angela Wong
  • Raju Vegesna
  • James D. Winkler
  • Joanna Balcarek
  • C. Frank Bennett
Part of the New Horizons in Therapeutics book series (NHTH)

Abstract

During the past several years, substantial progress has been reported in understanding the receptors and signal transduction processes for the peptidyl leukotriene (Crooke et al.,1987). Studies in our labortory have identified and characterized the receptors and the major steps in the signal transduction process. These studies have allowed us to propose a model explaining the interactions in LTD4 with its receptors and the events that are induced by these interactions (Fig. 1).

Keywords

U937 Cell Arachidonic Acid Release Signal Transduction Process Guanine Nucleotide Binding Protein Heterologous Desensitization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Stanley T. Crooke
    • 1
  • Seymour Mong
    • 1
  • Mike Clark
    • 1
  • Henry Sarau
    • 1
  • Angela Wong
    • 1
  • Raju Vegesna
    • 1
  • James D. Winkler
    • 1
  • Joanna Balcarek
    • 1
  • C. Frank Bennett
    • 1
  1. 1.Department of Molecular PharmacologySmith Kline & French LaboratoriesPhiladelphiaUSA

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