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Molecular Properties of Leukocyte Receptors for Leukotrienes

  • Catherine H. Koo
  • Laurent Baud
  • Jeffrey W. Sherman
  • Jeanne P. Harvey
  • Daniel W. Goldman
  • Edward J. Goetzl
Part of the New Horizons in Therapeutics book series (NHTH)

Abstract

The products of oxygenation of arachidonic acid constitute the most diverse family of inflammatory mediators, that are generated by many different pathways in almost all types of cells and are potent initiators and modulators of numerous biological functions. Distinct lipoxygenases convert arachidonic acid to an array of monohydroxy-eicosatetraenoic acids (HETEs) (see Appendix for list of abbreviations), di- and tri-HETEs, and peptide conjugates of HETEs, which participate with different functions in inflammatory and hypersensitivity reactions. The most potent of the arachidonic-acid-derived mediators of chemotaxis and other leukocyte functions is 5(S), 12(R)-dihydroxy-eicosa-6,14 cis-8,10-trans-tetraenoic acid or leukotriene B4 (LTB4), which is produced by the 5-lipoxygenase systems predominating in human polymorphonuclear (PMN) leukocytes, macrophages, and mast cells (Samuelsson, 1983). The C-6-sulfidopeptide leukotrienes, LTC4, LTD4, and LTE4, from the 5-lipoxygenase cascade of mast cells and macrophages, are potent smooth muscle contractile and vasoactive factors but affect PMN leukocytes solely by increasing adherence to endothelial cells and other surfaces in vitro and in vivo (Goetzl et al., 1983; Samuelsson, 1983; Hayaishi and Yamamoto, 1985). In contrast, the 15-lipoxygenase pathway is localized preferentially in epithelial cells of human skin, pulmonary airways, and the gastrointestinal tract (Burrall et al., 1985; Hunter et al., 1985; Krilis et al., 1986) and transforms arachidonic acid into 15-HETE and multiple isomers of 8,15-di-HETE and 14,15-di-HETE.

Keywords

HL60 Cell Pertussis Toxin Bovine Aortic Endothelial Cell Human Polymorphonuclear Leukocyte Human Promyelocytic Leukemia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Catherine H. Koo
    • 1
  • Laurent Baud
    • 1
  • Jeffrey W. Sherman
    • 1
  • Jeanne P. Harvey
    • 1
  • Daniel W. Goldman
    • 1
  • Edward J. Goetzl
    • 1
  1. 1.Howard Hughes Medical Institute and Departments of Medicine and Microbiology—ImmunologyUniversity of California Medical CenterSan FranciscoUSA

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