Cellular Interactions Regulating Inflammation

Activation of T Lymphocytes at Inflammatory Sites and Their Role in Perpetuating Chronic Inflammation
  • T. D. Geppert
  • P. E. Lipsky
Part of the New Horizons in Therapeutics book series (NHTH)


Chronic inflammation characteristic of a variety of diseases is driven by immunologic processes. The introduction of a foreign antigen initiates a cascade of events that results in various manifestations of chronic inflammation. Central to this process is the T lymphocyte that recognizes antigen and is thereby triggered to undergo a series of morphologic and metabolic changes. Once activated, the T lymphocyte plays a central role in the initiation and maintenance of immunologically mediated inflammation. One mechanism whereby activated T lymphocytes propagate the inflammatory response is the production of lymphokines. Lymphokines are antigen-nonspecific-secreted products that exert effects on a variety of cell types that bear specific receptors for various lymphokines. Lymphokines may affect cells of the same lineage or different cell types both inside and outside the immune system. Moreover, some lymphokines have a variety of effects on several different cell types.


Major Histocompatibility Complex Cellular Interaction Major Histocompatibility Complex Molecule Accessory Cell Cell Antigen Receptor 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • T. D. Geppert
    • 1
  • P. E. Lipsky
    • 1
  1. 1.Harold C. Simmons Arthritis Research CenterUniversity of Texas Health Science Center at Dallas, Southwestern Medical SchoolDallasUSA

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