Animal Extrapolation and the Challenge of Human Interindividual Variation

  • Edward J. Calabrese
Part of the Contemporary Issues in Risk Analysis book series (CIRA, volume 3)


There are a number of biological factors which may enhance one’s susceptibility to experience adverse health effects from exposure to toxic substances, including car cinogens. These include one’s age, sex, genetic composition, nutritional status, and preexisting disease conditions (Calabrese, 1978, 1984, 1985, 1986; Propping, 1978).


Bladder Cancer Aromatic Amine Metabolic Ratio Slow Acetylator Acetylator Phenotype 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Edward J. Calabrese
    • 1
  1. 1.Environmental Science Program, Division of Public HealthUniversity of MassachusettsAmherstUSA

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