Two-Compartment Analysis of \(\dot V_A /\dot Q\) Inequality and Transient Blood-Gas Differences
Numerous\(\dot V_A /\dot Q\) models have been proposed and utilized to explain steady state gas exchange in mammalian lungs. These models vary in the number of conceptualized lung compartments, the experimental sophistication required to obtain the necessary input data, and the complexity of numerical solutions. We have incorporated classical gas exchange concepts and mathematical techniques from other recent models to obtain a simplified two-compartment model which requires only standard gas exchange measurements as input variables. The \(\dot V_A /\dot Q\) ratios and other relevant blood and gas values are then obtained for each compartment which are compatible with the input data (Loeppky et al., 1987).
KeywordsSteady State Measurement Baseline Steady State
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- Briscoe, W.A., E.M. Cree, J. Filler, H.E. Houssay and A. Cournand (1960). Lung volume, alveolar ventilation and perfusion interrelationships in chronic pulmonary emphysema. J. Appl. Physiol. 15:785–795.Google Scholar
- Loeppky, J.A., A. Caprihan and U.C. Luft (1987). \(\dot V_A /\dot Q\)inequality during clinical hypoxema and its alterations. In:Man in Stressful Environments, edited by K. Shiraki and M. K. Yousef. Springfield, IL, C.C. Thomas, in press.Google Scholar
- Olszowka, A.J. and P.D. Wagner (1980). Numerical analysis of gas exchange. In:Pulmonary Gas Exchange, Vol. I,Ventilation, Blood Flow, and Diffusion, edited by J.B. West. New York, Academic Press, pp. 263–306.Google Scholar
- Piiper, J. and P. Scheid (1980). Blood-gas equilibration in lungs. In: Pulmonary Gas Exchange, Vol. I,Ventilation, Blood Flow, and Diffusion,edited by J.B. West. New York, Academic Press, pp. 131–171.Google Scholar
- Rahn, H. and W.O. Fenn (1955). A Graphical Analysis of the Respiratory Gas Exchange: The O2-CO2 Diagram. Washington, D.C., Amer. Physiol. Society.Google Scholar
- Wagner, P.D. and J.B. West (1980). Ventilation-perfusion relationships. In:Pulmonary Gas Exchange. Vol. I,Ventilation, Blood Flow, and Diffusion, edited by J.B. West. New York, Academic Press, pp. 219–262.Google Scholar