Thermoregulation and Metabolism in Hypoxic Animals

  • R. K. Dupre
  • A. M. Romero
  • S. C. Wood
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 227)


It is well established that altered body temperature (Tb) has an exponential effect on the oxygen consumption (\({\dot V}\)O2) of resting animals (Krogh, 1914). Alterations of Tb over a range larger than 20°C are routine for ectothermic vertebrates. The range of altered core Tb is smaller for homeotherms but is still significant in hyperthermia and hypothermia. In general, a l°C change in Tb causes an 11% change in metabolic rate (Q10 = 2.5). Consequently, fever or exercise-induced hyperthermia, will elevate oxygen demand and amplify the hypoxic stress of a mammal at high altitude or with cardiopulmonary disease. Conversely, hypothermia could be beneficial to any animal faced with a limited oxygen supply.


Oxygen Transport Respiratory Chamber Lower Critical Temperature Hypoxic Hypoxia Regulate Body Temperature 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • R. K. Dupre
    • 1
  • A. M. Romero
    • 1
  • S. C. Wood
    • 2
  1. 1.University of NevadaLas VegasUSA
  2. 2.Lovelace Medical FoundationAlbuquerqueUSA

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