Influence of Gas Physical Properties on Pulmonary Gas Exchange
The gas exchange properties of the lung depend on the relative uniformity of the matching of ventilation and perfusion in the individual acinar units. The exchange of inert gases in a homogeneous acinar unit is dependent on the physical properties of those inert gases. This presentation deals with three aspects of the inert gas physical properties governing their exchange. The primary determinant of inert gas exchange is the solubility of the gas in blood. Second, gas exchange is weakly dependent on the molecular weight of the gas. Finally, the exchange of the very soluble inert gases depends on interaction of gas with the airways as air passes through the airways during inspiration and expiration.
KeywordsDead Space High Frequency Ventilation Breath Alcohol Concentration Bronchial Blood Flow Airway Temperature
Unable to display preview. Download preview PDF.
- Adaro, F. and L.E. Farhi (1971). Effects of intralobular gas diffusion on alveolar gas exchange. Fed. Proc. 30:437.Google Scholar
- Gard, R.G., M.P. Hlastala and A.L. Babb (1984). Heat and water exchange in an airway tissue model. Physiologist 27:259.Google Scholar
- Hlastala, M.P., P. Scheid and J. Piiper (1981). Interpretation of inert gas retention and excretion in the presence of stratified inhomogeneity. Respir. Physiol. 46:247–259.Google Scholar
- Hlastala, M.P., H.P. McKenna, M. Middaugh and H.T. Robertson (1982). Role of diffusion dependent inhomogeneity in gas exchange in the dog. Bull Eur physiolpathol. Resp. 18:373–380.Google Scholar
- Jones, A.W. (1983b). Role of rebreathing in determination of the blood-breath ratio of expired ethanol. J. Appl. Physiol.: Respir. Environ. Exercise Physiol. 55:1237–1241.Google Scholar
- Robertson, H.T., D.D. Ralph and M.P. Hlastala (1986b). Diffusion dependent differences in the Fowler dead spaces of intravenously infused inert gases. Fed. Proc. 45:394.Google Scholar
- Scheid, P. and J. Piiper (1980). Intrapulmonary gas mixing and stratification. In: Pulmonary Gas Exchange. Ed: J.B. West, Vol. 1, pp 87–130.Google Scholar
- Slemeyer, A. (1981). An analytical model describing the exchange processes of alcohol in the respiratory system. Alcohol, Drugs and Traffic Safety. Ed: L. Goldberg. Almqvist and Wiksell International, pp. 456–468.Google Scholar
- Swenson, E.R., H.T.R. Robertson and M.P. Hlastala (1986). Gas exchange in the in situ isolated trachea. Amer. Rev. Resp. Dis. 133:A27.Google Scholar
- Truog, W.E., M.P. Hlastala, T.A. Standaert, H.P. McKenna and W.A. Hodson (1979). Oxygen induced alteration of ventilation-perfusion relationships in rats. J. Appl. Physiol: Respirat. Environ. Exercise Physiol. 47:1112–1117.Google Scholar
- Tsu, M.E., A.L. Babb, D.D. Ralph and M.P. Hlastala (1987). Analysis of heat, water and soluble gas exchange in an airway. Fed. Proc. 46:1427.Google Scholar