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HCl Infusion Stimulates the Release of a Substance from the Blood Which Alters Breathing and Blood Pressure

  • James A. Orr
  • Hashim Shams
  • M. Roger Fedde
  • P. Scheid
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 227)

Abstract

Intravenous infusion of strong acids, such as hydrochloric acid, has been previously used by various investigators as a means to lower blood pH in the study of respiratory or cardiovascular responses to acidosis. A previous report from our laboratory has demonstrated that infusion of HCl at a constant circulating blood pH causes the release of a substance from the blood that affects breathing and blood pressure (Orr et al., 1987). Repeated infusion of HCl in the same animal failed to elicit the response, either because the causative agent was depleted during the initial infusion or because the animal became refractory to the agent.

Keywords

Tidal Volume Strong Acid Cardiovascular Response Initial Infusion Arachidonic Acid Metabolite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Orr, J.A., H. Shams, M.R. Fedde and P. Scheid. (1987). Cardiorespiratory changes during HCl infusion unrelated to decreases in circulating blood pH. J. Appl. Physiol. 62:2362–2370.PubMedGoogle Scholar
  2. Moncada, S., R.J. Flower and J.R. Vane. (1985). Prostaglandins, prostacyclin, thromboxane A2 and leukotrienes. In: Goodman and Gilman’s The Pharmacological Basis of Therapeutics Goodman, T.W. Rail and F. Murad. Seventh Ed. MacMillan Pub. Co.: New York, pp. 660–673.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • James A. Orr
    • 1
  • Hashim Shams
    • 1
    • 2
  • M. Roger Fedde
    • 1
    • 3
  • P. Scheid
    • 1
    • 2
  1. 1.University of KansasLawrenceUSA
  2. 2.Ruhr-Universitat BochumFederal Republic of Germany
  3. 3.Kansas State UniversityManhattanUSA

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