Problems with the Hyperventilatory Response to Exercise and Hypoxia

  • Jerome A. Dempsey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 227)


To achieve the optimal ventilatory response to heavy exercise, several criteria must be satisfied. First, alveolar hyperventilation must be adequate to meet not only the rising CO2 flow to the lungs but also to compensate the progressive development of metabolic acidosis and to ensure a high overall \(\rm\dot{v}\)A/\(\rm\dot{Q}\)C and diffusion gradient in the face of marked reductions in mixed venous PO2 and shortened capillary transit time. Secondly, the mechanical limits of the lung and chest wall — in terms of respiratory muscle force, energy stores and rate of energy supply — must be sufficient to meet these ventilatory demands. Third, the regulation of respiratory muscle length and the timing of muscle contraction must be regulated so as to optimize chest wall function.


Respiratory Muscle Ventilatory Response Hypoxic Exposure Acute Hypoxia Inspiratory Muscle 
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  1. Arias-Stella, J. and J. Valcancel (1973). The human carotid body at high altitudes. Pathologia and Microbiologia 39:292.Google Scholar
  2. Berssenbrugge, A., J.A. Dempsey and J.B. Skatrud (1984). Effects of sleep state on ventilatory acclimatization to chronic hypoxia. J. Appl. Physiol. 57:1089–1096.PubMedGoogle Scholar
  3. Cerny, F.C., J.A. Dempsey and W.G. Reddan (1973). Pulmonary gas exchange in non-native residents of high altitude. J. Clin. Invest. 52:2993–2999.PubMedCrossRefGoogle Scholar
  4. Dempsey, J.A. (1986). Is the lung built for exercise? Med. Sci. Sports 18:143–155.CrossRefGoogle Scholar
  5. Dempsey, J.A. and J.B. Skatrud (1986). A sleep-induced apneic threshold and its consequences. Am. Rev. Respir. Dis. 133:1163–1170.PubMedGoogle Scholar
  6. Dempsey, J.A., E.H. Vidruk and G.S. Mitchell (1985). Pulmonary control systems in exercise: update. Fed. Proc. 44:2260–2270.PubMedGoogle Scholar
  7. Dempsey, J.A., P. Hanson and K. Henderson (1984). Exercise-induced arterial hypoxemia in healthy human subjects at sea-level. J. Physiol. (Lond.) 355:161–175.Google Scholar
  8. Dempsey, J.A. N. Gledhill, W.G. Reddan, H.V. Forster, P.G. Hanson and A.D. Claremont (1977). Pulmonary adaptation to exercise: effects of exercise type and duration, chronic hypoxia, and physical training. Ann. NY Acad. Sci. 301:243.PubMedCrossRefGoogle Scholar
  9. Dempsey, J.A., J.M. Thomson, H.V. Forster, F.C. Cerny and L.W. Chosy (1975). Hbo2 dissociation in man during prolonged work in chronic hypoxia. J. Appl. Physiol. 38:1022–1029.PubMedGoogle Scholar
  10. Dempsey, J.A., J.M. Thomson, S.C. Alexander, H.V. Forster and L.W. Chosy (1975). Respiratory influences on acid-base status and their effects on O2 transport during prolonged muscular work. In: Metabolic Adaptation to Prolonged Physical Exercise. Proceedings of the 2nd International Symposium on Biochemistry of Exercise. H. Howald and J.R. Poortmans (Eds). Magglingen, Switzerland: Number 7, pp. 56–64.Google Scholar
  11. Dempsey, J.A., W.G. Reddan, J. Rankin, M.L. Birnbaum, H.V. Forster, J.S. Thoden and R.F. Grover (1971). Effects of acute through life-long hypoxic exposure on exercise pulmonary gas exchange. Respir. Physiol. 13:62–89.PubMedCrossRefGoogle Scholar
  12. Fregosi, R.F. and J.A. Dempsey (1986). Effects of exercise in normoxia and acute hypoxia on respiratory muscle metabolites. J. Appl. Physiol. 60(4):1274–1283.PubMedCrossRefGoogle Scholar
  13. Garfinkel, R. and R.S. Fitzgerald (1978). The effect of hypoxemia, hypoxia and hypercapnia on FRC and occlusion pressure in human subjects. Resp. Physiol. 33:241–250.CrossRefGoogle Scholar
  14. Grimby, G., B. Saltin and L.W. Helmsen (1971). Pulmonary flow-volume and pressure-volume relationships during submaximal and maximal exercise in young well-trained men. Bull. Physiol-Pathol. Respir. 7:157–168.Google Scholar
  15. Grimby, G., M. Goldman and J. Mead (1976). Respiratory muscle actions inferred from rib cage and abdominal V-P partitioning. J. Appl. Physiol. 41:739–751.PubMedGoogle Scholar
  16. Holtgren A. and R.F. Grover (1971). Abnormal circulatory responses to high altitude in subjects with a previous history of high altitude pulmonary edema. Circulation 44:759–770.Google Scholar
  17. Henke, K., M. Sharratt, D. Pegelow and J. Dempsey (1987). Regulation of end-expiratory lung volume during exercise. Fed. Proc. 46(3):1018 (abs).Google Scholar
  18. Lahiri, S., K. Maret and M. Sherpa (1983). Dependence of high altitude sleep apnea on ventilatory sensitivity of hypoxia. Respir. Physiol. 52:281–288.PubMedCrossRefGoogle Scholar
  19. Milic-Emili, J. Petit and R. Deroanne (1962). Mechanical work of breathing during exercise in trained and untrained subjects. J. Appl. Physiol. 17:43–46.PubMedGoogle Scholar
  20. Pardy, R.L., S.N. Hussain and P.T. Macklem (1984). The ventilatory pump in exercise. In: Clinics in Chest Medicine. J. Loke (Ed). 5:35–49.Google Scholar
  21. Smith, C.A., D. Ainsworth, K. Henderson and J. Dempsey (1987). Differential recruitment of expiratory muscles. Fed. Proc. 46(3):1968 (abs).Google Scholar
  22. Thoden, J.S., J.A. Dempsey, W.G. Reddan, M.L. Birnbaum, H.V. Forster, R.F. Grover and J. Rankin (1969). Ventilatory work during steady-state response to exercise. Fed. Proc. 28:1316–132.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jerome A. Dempsey
    • 1
  1. 1.John Rankin Laboratory of Pulmonary Medicine Department of Preventive MedicineUniversity of WisconsinMadisonUSA

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