An Integrated View of the Determinants of Maximum Oxygen Uptake
When one considers the pathway for transfer of O2 from the atmosphere to the mitochondria, several distinct and sequential steps are classically identified: 1) convective gas flow of O2 to the alveoli by ventilation. 2) diffusive gas mixing and transfer across the blood gas barrier into the capillary blood, 3) convective transport in the blood to the peripheral tissues, and 4) diffusive movement out of the tissue capillary to the mitochondria where O2 is utilized.
KeywordsOxygen Uptake Oxygen Delivery Maximum Oxygen Uptake Simulated Altitude Arterial Oxygen Content
Unable to display preview. Download preview PDF.
- Anderson, P. and B. Saltin (1985). Maximal perfusion of skeletal muscle in man. J. Physiol. 366:233–249.Google Scholar
- Banchero, N. (1975). Capillary density of skeletal muscle in dogs exposed to simulated altitude. Proc. Soc. Exp. Biol. N.Y. 148:435–439.Google Scholar
- Gledhill, N. (1982). Blood doping and related issues: a brief review. Med. Sci. Sports Exercise 14(3):183–189.Google Scholar
- Hogan, M.C., J. Roca, P.D. Wagner and J.B. West (1987). Dissociation of VO2max from O2 delivery in isolated, in situ canine gastrocnemius. Submitted to American Physiological Society Annual Fall Meeting, October 11–15.Google Scholar
- Kaijser, L. (1970). Limiting factors for aerobic muscle performance. The influence of varying oxygen pressure and temperature. Acta Physiol. Scand. Suppl. 3246:1–96.Google Scholar
- Sutton, J.R., J.T. Reeves, P.D. Wagner, B.M. Groves, A. Cymerman, P. Young, M.K. Malconian and C.S. Houston (1986). Oxygen uptake during exercise at extreme simulated altitude is maintained by marked reduction in mixed venous oxygen tension - Operation Everest II. Fed. Proc. 45:4231.Google Scholar
- Wagner, P.D., J.T. Reeves, J.R. Sutton, A. Cymerman, B.M]Groves, M.K. Malconian and P.M. Young (1986). Possible limitation of maximal O2 uptake by peripheral tissue diffusion. Am. Rev. Respir. Dis. 133: A202.Google Scholar
- Welch, H.G. (1982). Hyperoxia and human performance: a brief review. Med. Sci. Sports Exercise 14:253–262.Google Scholar
- Williams, M.H., S. Wesseldine, T. Somma and R. Schuster (1981). The effect of induced erythrocytemia upon 5-mile treadmill run time. Med. Sci. Sports Exercise 13:169–175.Google Scholar