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The Total Ionic Status of Muscle During Intense Exercise

  • G. J. F. Heigenhauser
  • M. I. Lindinger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 227)

Abstract

During intense exercise, the high rate of glycolysis results in a large accumulation of intracellular lactate (La-) and increased hydrogen ion concentration (H+]) (Spriet et al., 1985). High intracellular [H+] during heavy exercise has often been implicated as a cause of muscle fatigue. A number of loci for fatigue have been suggested: excitation-contraction coupling (Fabiato and Fabiato, 1978), control of glycolytic flux at the level of Phosphorylase (Chasiotis et al., 1983) and phosphofructokinase (Trivedi and Danforth, 1966) and impairment of ionic pumps and exchanges on the sarcoplasmic reticulum and sarcolemma (Nakamura and Schwartz, 1972).

Keywords

Sarcoplasmic Reticulum Instrumental Neutron Activation Analysis Intense Exercise Glycolytic Flux Heavy Exercise 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Astrand, P.-O., E. Hultman, A. Juhlin-Dannfelt and G. Reynolds (1986). Disposal of lactate during and after strenuous exercise in humans. J. Appl. Physiol. 61:338–343.PubMedGoogle Scholar
  2. Chasiotis, D., E. Hultman and K. Sahlin (1983). Acidotic depression of cyclic AMP accumulation and Phosphorylase b to a transformation in skeletal muscle of man. J. Physiol. (Lond.) 335:197–204.Google Scholar
  3. Fabiato, A. and F. Fabiato (1978). Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiac and skeletal muscles. J. Physiol. (London).Google Scholar
  4. Kachmar, J.F. and P.D. Boyer (1953). Kinetic analysis of enzyme reactions. II. The potassium activation and calcium inhibition of pyruvic phosphoferase. J. Biol. Chem. 200:669–682.PubMedGoogle Scholar
  5. Lindinger, M.I., M. Ganagarajah and G.J.F. Heigenhauser (1987). Determinants of intramuscular H+ concentration. Med. Sci. Sports Exerc. 19:S27.Google Scholar
  6. Lindingerr M.I. and G.J.F. Heigenhauser (1987). Intracellular ion content of skeletal muscle measured by instrumental neutron activation analysis. J. Appl. Physiol. 63:426–433.Google Scholar
  7. Lindingerr M.I., G.J.F. Heigenhauser and N.L. Jones (1986). Acid-base and respiratory properties of a buffered bovine erythrocyte perfusion medium. Can. J. Physiol. Pharmacol. 64:550–555.CrossRefGoogle Scholar
  8. Mildvan, A.S. (1974). Mechanism of enzyme action. Ann. Rev. Biochem. 43:357–399.PubMedCrossRefGoogle Scholar
  9. Nakamura, Y. and A Schwartz (1972). The influence of hydrogen ion concentration on calcium binding and release by skeletal muscle sarcoplasmic reticulum. J. Gen. Physiol. 59:22–32.CrossRefGoogle Scholar
  10. Spriet, L.L., C.G. Matsos, S.J. Peters, G.J.F. Heigenhauser and N.L. Jones (1985). Muscle metabolism and performance in perfused rat hindquarter during heavy exercise. Am. J. Physiol. 248:C109-C118.PubMedGoogle Scholar
  11. Stewart, P.A. (1981). How to Understand Acid-Base: A Quantitative Primer for Biology and Medicine. New York: Elsevier North Holland.Google Scholar
  12. Stewart, P.A. (1983). Modern quantitative acid-base chemistry. Can. J. Physiol. Pharmacol. 61:1444–1461.PubMedCrossRefGoogle Scholar
  13. Trivedi, B. and W.H. Danforth (1966). Effect of pH on the kinetics of frog muscle phosphofructokinase. J. Biol. Chem. 241:4110–4112.PubMedGoogle Scholar
  14. Wilkie, D.R (1986). Muscular fatigue: effects of hydrogen ions and inorganic phosphate. Fed. Proc. 45:2921–2923.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • G. J. F. Heigenhauser
    • 1
  • M. I. Lindinger
    • 1
  1. 1.Department of MedicineMcMaster University Medical CentreHamiltonCanada

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