Pulmonary Diffusing Capacity and Alveolar-Capillary Equilibration

  • Johannes Piiper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 227)


In this short overview, theoretical and experimental work by the author and his co-workers pertaining to alveolar-capillary equilibration in mammalian lungs is summarized. The report is subdivided into four sections, each dealing with a different aspect of the topic: I. Diffusing capacity and diffusion/perfusion model. II. Determination of pulmonary diffusing capacity by rebreathing. III. O2 kinetics of red blood cells measured by stopped-flow. IV. Alveolar-capillary CO2 equilibration. The topics of the sections I, II and IV have been previously reviewed in more detail (Piiper and Scheid, 1980).


Diffusion Limitation Diffuse Capacity Pulmonary Blood Flow Diffusion Conductance Rebreathing Method 
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  1. Adaro, F., P. Scheid, J. Teichmann and J. Piiper (1973). A rebreathing method for estimating pulmonary DO2: theory and measurements in dog lungs. Respir. Physiol. 18:43–63.PubMedCrossRefGoogle Scholar
  2. Cerretelli, P. (1976). Limiting factors to oxygen transport on Mount Everest. J. Appl. Physiol. 40:658–667.PubMedGoogle Scholar
  3. Cerretelli, P., A. Veicsteinas, J. Teichmann, H. Magnussen and J. Piiper (1974). Estimation by a rebreathing method of pulmonary O2 diffusing capacity in man. J. Appl. Physiol. 37:526–532.PubMedGoogle Scholar
  4. Chinet, A., J. L. Micheli and P. Haab (1971). Inhomogeneity effects on and CO pulmonary diffusing capacity estimates by steady-state methods. Theory. Respir. Physiol. 13:1–22.CrossRefGoogle Scholar
  5. Coin, J.T. and J.S. Olson (1979). The rate of oxygen uptake by human red blood cells. J. Biol. Chem. 254:1178–1190.PubMedGoogle Scholar
  6. Geiser, J., H. Schibli and P. Haab (1983). Pulmonary O2 diffusing capacity estimates from assumed lognormal V, Q and D distributions. Respir. Physiol. 52:53–67.PubMedCrossRefGoogle Scholar
  7. Hammond, M.D., G.E. Gale, K.S. Kapitan, A. Ries and P.D. Wagner (1986). Pulmonary gas exchange in humans during normobaric hypoxic exercise. J. Appl. Physiol. 61:1749–1757.PubMedGoogle Scholar
  8. Holland, R.A.B., H. Shibata, P. Scheid and J. Piiper (1985). Kinetics of O2 uptake and release by red cells in stopped-flow apparatus: effects of unstirred layer. Respir. Physiol. 59:71–91.PubMedCrossRefGoogle Scholar
  9. Huxley, B.H. and H. Kutchai (1981). The effect of the red cell membrane and a diffusion boundary layer on the rate of oxygen uptake by human erythrocytes. J. Physiol. London 316:75–88.PubMedGoogle Scholar
  10. Huxleyr V.H. and H. Kutchai (1983). Effect of diffusion boundary layers on the initial uptake of O2 by red cells. Theory versus experiments. Microvasc. Res. 26:89–107.CrossRefGoogle Scholar
  11. Meyer, M., P. Scheid, G. Riepl, H.J. Wagner and J. Piiper (1981). Pulmonary diffusing capacities for O2, and CO2, measured by a rebreathing technique. J. Appl. Physiol. 51:1643–1650.PubMedGoogle Scholar
  12. Mochizuki, M. (1966). Study on the oxygenation velocity of the human red cell. Jpn. J. Physiol. 16:635–648.PubMedCrossRefGoogle Scholar
  13. Piiper, J., P. Dejours, P. Haab and H. Rahn (1971). Concepts and basic quantities in gas exchange physiology. Respir. Physiol. 13:292–304.PubMedCrossRefGoogle Scholar
  14. Piiper, J., M. Meyer, C. Marconi and P. Scheid (1980). Alveolar-capillary equilibration kinetics of I3-CO2 in human lungs studied by rebreathing. Respir. Physiol. 42:29–41.PubMedCrossRefGoogle Scholar
  15. Piiper, J. and P. Scheid (1980). Blood-gas equilibration in lungs. In: Pulmonary Gas Exchange. Volume I. Ventilation, Blood Flow and Diffusion, ed. by J.B. West. New York, Academic Press, pp. 131–171.Google Scholar
  16. Piiper, J. and P. Scheid (1981). Model for capillary-alveolar equilibration with special reference to O2 uptake in hypoxia. Respir. Physiol. 46:193–208.PubMedCrossRefGoogle Scholar
  17. Piiper, J. and P. Scheid (1983). Comparison of diffusion and perfusion limitations in alveolar gas exchange. Respir. Physiol. 51:287–290.PubMedCrossRefGoogle Scholar
  18. Rice, S. (1980). Hydrodynamic and diffusion considerations of rapid-mix experiments with red blood cells. Biophys. J. 29:65–78.PubMedCrossRefGoogle Scholar
  19. Roughton, F.J.W. and R.E. Forster (1957). Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries. J. Appl. Physiol. 11:290–302.PubMedGoogle Scholar
  20. Savoy, J., M.C. Michoud, M. Robert, J. Geiser, P. Haab and J. Piiper (1980). Comparison of steady state pulmonary diffusing capacity estimates for O2 and CO in dogs. Respir. Physiol. 42:43–59.PubMedCrossRefGoogle Scholar
  21. Schuster, K.D. (1985). Kinetics of pulmonary CO2 transfer studied by using labeled carbon dioxide C-16–0-18–0. Respir. Physiol. 60:21–37.PubMedCrossRefGoogle Scholar
  22. Schuster, K.D. (1987). Diffusion limitation and limitation by chemical reactions during alveolar-capillary transfer of oxygen-labeled CO2. Respir. Physiol. 67:13–22.PubMedCrossRefGoogle Scholar
  23. Staub, N.C., J.M. Bishop and R.E. Forster (1962). Importance of diffusion and chemical reaction rates in O2 uptake in the lung. J. Appl. Physiol. 17:21–27.PubMedGoogle Scholar
  24. Teichmann, J., F. Adaro, A. Veicsteinas, P. Cerretelli and J. Piiper (1974). Determination of pulmonary blood flow by rebreathing of soluble inert gases. Respiration 31:296–309.PubMedCrossRefGoogle Scholar
  25. Torre-Bueno, J., P.D. Wagner, H.A. Saltzman, G.E. Gale and R.E. Moon (1985). Diffusion limitation in normal humans during exercise at sea level and simulated altitude. J. Appl. Physiol. 58:989–995.PubMedGoogle Scholar
  26. Vandegriff, K.D. and J.S. Olson (1984a). The kinetics of O2 release by human red blood cells in the presence of external sodium dithionite. J. Biol. Chem. 259:12609–12618.PubMedGoogle Scholar
  27. Vandegriff, K.D. and J.S. Olson (1984b). Morphological and physiological factors affecting oxygen uptake and release by red blood cells. J. Biol. Chem. 259:12619–12627.PubMedGoogle Scholar
  28. Vandegriff, K.D. and J.S. Olson (1984c). A quantitative description in three dimensions of oxygen uptake by human red blood cells. Biophys. J. 45:825–835.PubMedCrossRefGoogle Scholar
  29. Wagner, P.D., G.E. Gale, R.E. Moon, J.R. Torre-Bueno, B.W. Stolp and H.A. Saltzman (1986). Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J. Appl. Physiol. 61:260–270.PubMedGoogle Scholar
  30. Yamaguchi, K., D. Nguyen-Phu, P. Scheid and J. Piiper (1985). Kinetics of O2 uptake and release by human red blood cells studied by a stopped-flow technique. J. Appl. Physiol. 58:1215–1224.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Johannes Piiper
    • 1
  1. 1.Max Planck Institute for Experimental MedicineGöttingenFederal Republic of Germany

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