Critical P\(\rm\bar{v}\)O2 VS Critical Oxygen Transport with Acute Hypoxia in Anesthetized Animals

  • Esther P. Hill
  • David C. Willford
  • Francis C. White
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 227)


Oxygen delivery to peripheral tissues has often been described in terms of either the amount of oxygen delivered by the arterial blood or of that exiting the tissues on the venous side, because direct tissue oxygen measurements are often not feasible. Since the early studies of Verzar (1912) and Krogh (1919), physiologists have often assumed that mixed venous PO2 (P\(\rm\bar{V}\)O2) reflects average tissue PO2, but that assumption is certainly an oversimplification of a very complex situation (Tenney, 1974; Miller, 1982; Cain, 1983). Other attempts to quantitate oxygenation have concentrated instead on the arterial system by calculating the total oxygen transport (TOT) in ml/min as the product of blood flow rate (\(\rm\dot{Q}\), in dl/min) and the arterial oxygen concentration (CaO2, in ml/dl):
$$\text{TOT}\,\text{ = }\,\dot Q^. CaO_2$$
$$\cong \,1.34\,\dot Q\,[Hb]\,SaO_2$$
where [Hb] is the hemoglobin concentration in gm/dl and SaO2 is the fractional oxyhemoglobin saturation in arterial blood. This product has also been termed “oxygen transport”, “oxygen availability”, and “oxygen delivery” by various authors.


Oxygen Delivery Oxygen Consumption Rate Stagnant Hypoxia Mixed Venous Blood Hypoxic Hypoxia 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Esther P. Hill
    • 1
  • David C. Willford
    • 1
  • Francis C. White
    • 1
  1. 1.Department of MedicineUniversity of CaliforniaSan Diego La JollaUSA

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