The Relationship of Tissue Oxygenation to Cellular Bioenergetics

  • Guillermo Gutierrez
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 227)


As primeval cellular organisms coalesced into complex entities, the diffusion distance from atmosphere to the energy producing organelles increased. This resulted in the evolution of an elaborate mass transport system with the dual purpose of carrying oxygen to the mitochondria and removing one of the biproducts of metabolism, carbon dioxide. This gas transport system has allowed man and other living creatures to thrive under a wide range of environmental conditions. However, the delivery of O2 to the tissues may be compromised when the limits of adaptation are reached. This may occur in high altitude, space travel, or when disease is present. Under those conditions the resulting tissue hypoxia results in a series of microvascular responses which help to preserve the flow of energy to the mechanisms responsible for maintaining the integrity of the cell membrane (Duling and Klitzman, 1980; Kontos 1986).


Magnetic Resonance Spectroscopy Oxidative Phosphorylation Oxygen Delivery Tissue Oxygenation Oxygen Transport 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Guillermo Gutierrez
    • 1
  1. 1.Department of Internal MedicineUniversity of Texas Health Science CenterHoustonUSA

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