Evaluation of Biochemical Processes by NMR

  • Albert L. Busza
  • Terence A. English
  • Jim Foreman
  • Barry J. Fuller
  • David G. Gadian
  • Edward Proctor
  • David E. Pegg
  • Derek Wheeldon
  • Stephen R. Williams
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 147)


Phosphorus nuclear magnetic resonance (31P NMR) is finding increasing application as a non-invasive method of studying metabolism in living systems. 31P spectra include signals from ATP, phosphocreatine (in muscle and brain), and inorganic phosphate, and in addition to monitoring the relative concentrations of these metabolites, it is also possible to measure the intracellular pH. The technique is therefore ideally suited to examining the changes in high energy phosphates and pH that are associated with periods of ischaemia, anoxia, or hypoxia.


Cold Storage Rabbit Heart Cardioplegic Solution Preservation Solution High Energy Phosphate 


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Albert L. Busza
    • 1
  • Terence A. English
    • 2
  • Jim Foreman
    • 3
  • Barry J. Fuller
    • 4
  • David G. Gadian
    • 1
  • Edward Proctor
    • 5
  • David E. Pegg
    • 3
  • Derek Wheeldon
    • 2
  • Stephen R. Williams
    • 1
  1. 1.Department of Physics in relation to SurgeryRoyal College of Surgeons of EnglandLondonUK
  2. 2.Heart Transplant Research UnitPapworth HospitalCambridgeUK
  3. 3.MRC Medical Cryobiology GroupUniversity Department of SurgeryCambridgeUK
  4. 4.Academic Department of SurgeryRoyal Free Hospital Medical SchoolLondonUK
  5. 5.Department of Applied Physiology and Surgical SciencesRoyal College of Surgeons of EnglandLondonUK

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