Nuclear Magnetic Resonance (NMR) Imaging of Perfusion
Nuclear magnetic resonance imaging has the potential to assess the blood flow in the microcirculation of preserved organs prior to implantation. Nuclear magnetic resonance (NMR) is inherently sensitive to motion of the nuclear spins through regions having different magnetic field strengths. NMR imaging relies on magnetic field gradients for spatial location information. Consequently, the flow of blood in the microcirculation may be observed with NMR imaging. Although this is a relatively new application of NMR imaging, the most successful approaches are based on adaptations of techniques of diffusion measurement by NMR. This chapter reviews three topics: 1) NMR imaging, 2) the analogy of the motion of blood in the microcirculation to molecular diffusion, and 3) measurement of the diffusion coefficient with NMR. Then, the work of Le Bihan on NMR imaging of perfusion is described.
KeywordsNuclear Magnetic Resonance Phase Shift Apparent Diffusion Coefficient Magnetic Field Gradient Nuclear Magnetic Resonance Signal
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