Modeling First-Pass Metabolism
Table 1 lists 66 drugs which exhibit a first-pass effect. A reasonable definition of a first-pass drug is one that exhibits a significant arterial-venous concentration difference at steady-state. Also, after oral administration, and when there is complete absorption of the dose, the area under the blood concentration-time curve is less than the area under the curve when the drug is administered intravenously at the same dose. Figure 1 depicts the meaning of the area (AUC).
KeywordsTimolol Maleate Dihydroergotamine Mesylate Sinusoidal Perfusion Butorphanol Tartrate Venous Equilibration
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