Pharmacokinetic Studies in Man

  • John G. Wagner
Part of the NATO ASI Series book series (NSSA, volume 145)


When I was invited to present this lecture, I went through my listing of over 300 articles and found that 62 of those articles were involved with original research papers involving human studies on 40 different drugs. I chose 21 of the 62 articles to present today. Before I discuss individual human studies, I wish to provide some background information.


Molar Equivalent Tetracycline Hydrochloride Enteric Coated Tablet Tolmetin Sodium Average Plasma Concentration 
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  1. J.G. Wagner et al, The effect of the dosage form on serum levels of indoxole, Clin. Pharmacol. Ther. 7: 610–619 (1966).PubMedGoogle Scholar
  2. J.G. Wagner et al, Serum concentrations after rectal administration of lincomycin hydrochloride J. Clin. Pharmacol. 8: 154–163 (1968).Google Scholar
  3. J.G. Wagner et al, Absorption, excretion and halflife of clinimycin in normal adult males, Am. J. Med. Sci. 256: 25–37 (1968)/CrossRefGoogle Scholar
  4. J.G. Wagner et al, Relative absorption of both tetracycline and penicillin G administered rectally in aqueous solution, Int. J. Clin. Pharmacol. 2: 44–51 (1969).Google Scholar
  5. J.G. Wagner, Some experiences in the evaluation of dosage forms of drugs in man, Compilation of Symposia Papers Presented at the 5th National Meeting of: A.Ph.A. Academy of Pharmaceutical Sciences, American Pharmaceutical Association, Academy of Pharmaceutical Sciences, Washington, D.C., 1970, pp. 420–465.Google Scholar
  6. N. Gerber and J. G. Wagner, Explanation of the dose-dependent decline of diphenylhydantoin plasma levels by fitting to the integrated form of the Michaelis-Menten equation, Res. Comm. Chem. Path. Pharmacol. 3: 455–466 (1972).Google Scholar
  7. J.G. Wagner et al, Equivalence lack in digoxin plasma levels, J. Am. Med. Assoc. 224: 199–204 (1973) .CrossRefGoogle Scholar
  8. J.G. Wagner et al, Failure of the USP tablet disintegration test to predict performance in man, J. Pharm. Sci. 62: 859–860 (1973).PubMedCrossRefGoogle Scholar
  9. J.G. Wagner et al, Importance of the type of dosage form and saturable acetylation in determining the bioactivity of p-aminosalicyclic acid, Am. Rev. Resp. Dis. 108: 536–546 (1973) .PubMedGoogle Scholar
  10. K.S. Albert et al, Plasma concentrations of diphenylhydantoin, its p-hydroxylated metabolite and corresponding glucuronide in man, Res. Comm. Chem. Path. Pharmacol. 9: 463–470 (1974).Google Scholar
  11. K.S. Albert et al, Pharmacokinetics of diphenhydramine in man, J. Pharmacokin. Biopharm. 3: 159–170 (1975).Google Scholar
  12. J.G. Wagner et al, Elimination of alcohol from human blood, J. Pharm. Sci. 65: 152–154 (1976) .PubMedCrossRefGoogle Scholar
  13. P.K. Wilkinson et al, Blood ethanol concentrations during and following constant-rate intravenous infusion of ethanol, Clin. Pharmacol. Ther. 19: 213–223 (1976) .PubMedGoogle Scholar
  14. Y.-J. Lin et al, Effects of solid food on blood levels of alcohol in man; Res. Comm. Chem. PATH. Pharmacol. 13: 713–722 (1976).Google Scholar
  15. A.V. Tembo et al, Bioavailability of predniso- lone tablets, J. Pharmacokin. Biopharm. 5: 207–224 (1977)Google Scholar
  16. J.W. Ayres et al, Pharmacokinetics of tolmetin with and without concomitant administration of antacid in man, Eur. J. Clin. Pharmacol.Google Scholar
  17. J.W. Ayres et al, Circadian rhythm of urinary pH in man with and without chronic antacid administration, Eur. J. Clin. Pharmacol. 12: 415–420 (1977).PubMedCrossRefGoogle Scholar
  18. R.F. Bergstrom et al, Penicillamine kinetics in normal subjects, Clin. Pharmacol. Ther. 30: 404–413 (1981)PubMedCrossRefGoogle Scholar
  19. J.G. Wagner et al, Prediction of steady-state verpamil plasma concentrations in children and adults, Clin. Pharmacol. Ther. 32: 172–181 (1982).PubMedCrossRefGoogle Scholar
  20. G.F. Lockwood et al, Pharmacokinetics of ibuprofen in man. I. Free and total area/dose relationships, Clin. Pharmacol. Ther. 34: 97–103 (1983).PubMedCrossRefGoogle Scholar
  21. G.J. Szpunar et al, Pharmacokinetics of flurb- iprofen in man. I. Area/dose relationships. Biopharm. Drug Dispos. accepted October 24, 1986.Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • John G. Wagner
    • 1
  1. 1.Upjohn Center for Clinical Pharmacology, Medical SchoolUniversity of MichiganAnn ArborUSA

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