Differential Susceptibility: Implications for Epidemiology, Risk Assessment, and Public Policy
In conventional toxicologic analysis for acute toxicity, differential susceptibility is assumed as the explanation for the dose-response relationship. For example, if susceptibility to the fatal effects of a chemical substance is distributed normally in a population, then the dose-response relationship will follow the cumulative normal distribution and will appear linear on probit graph paper. Some of the explanation for the spread in susceptibility can lie in genetic factors such as the presence or absence of detoxifying enzymes, while the remainder is usually assumed to be associated with age, body morphology, general health status, and other environmental factors. Chance is not often assigned a significant role in acute toxicity.
KeywordsBladder Cancer Phenotypic Variation Liver Cancer Differential Susceptibility Bladder Cancer Patient
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