Risk Assessment: Short-Term Exposure at Various Ages
Studies to estimate tumor incidence are frequently conducted in rodents exposed daily to a chemical for approximately two years. Dosing may be followed by a period of several weeks to allow tumors to develop before terminating the study. Exposure of humans to many carcinogens may occur for less than a lifetime; from occupations, changing lifestyles, or accidents. The question arises as to how to estimate the risk of tumors for short-term exposure at various ages from lifetime chronic bioassays.
KeywordsDose Rate Vinyl Chloride Longe Exposure Tumor Incidence Carcinogenic Process
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