Gene-Environmental Interaction as a Cause of Human Variation
To Mendel has often been attributed the good luck or good judgment of choosing for study traits that were clearly alternative characters and that were free of environmental influence. Galton, on the other hand, studied characteristics that were complex and that often had the potential for alteration by the environment, so-called multifactorial traits. The Galtonian approach, although it uses ever more sophisticated statistical and computational tools, has provided little insight into the mode of action of individual genes. It has, of course, been useful in plant and animal breeding experiments to study the contributions of both genetic and environmental variation and, as we have heard at this symposium, may help us to estimate inherited risk.
KeywordsMegaloblastic Anemia Pyridoxal Phosphate Hypoxanthine Phosphoribosyl Transferase Sodium Cyanoborohydride Propionic Acidemia
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