Advertisement

The Use of Polymorphic Markers to Detect Genetic Variability

  • Robert C. Elston
Part of the Basic Life Sciences book series (BLSC, volume 43)

Abstract

In non-experimental organisms, such as humans, it is not an easy matter to demonstrate unequivocally that a genetic component is involved in the determination of a trait. Estimates of heritability are based on familial correlations on the assumption that non-genetic correlations between pairs of relatives can be allowed for statistically. There have been many recent advances in segregation analysis to detect single-gene effects, but it is still difficult to be certain that any apparent segregation is in fact due to an underlying genetic mechanism (Elston, 1986). The basic problem is that in general we cannot infer causal mechanisms from observational data (Kempthorne, 1978). However, the availability of polymorphic genetic markers allows us to circumvent this difficulty to a certain extent.

Keywords

Marker Locus Polymorphic Marker Marker Information Partial Regression Coefficient Disease Trait 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blackwelder, W. C. and Elston, R. C., 1982, Power and robustness of sibpair linkage tests and extension to larger sibships, Commun. Stat., Theor. Meth., 11:449.CrossRefGoogle Scholar
  2. Blackwelder, W. C. and Elston, R. C., 1985, A comparison of sib-pair linkage tests for disease susceptibility loci, Genet. Epid., 2:85.CrossRefGoogle Scholar
  3. Botstein, D, White, R. L., Skolnick, M. H., and Davis, R. W., 1980, Construction of a genetic linkage map in man using restriction fragment length polymorphisms, Am. J. Hum. Genet., 32:314.PubMedGoogle Scholar
  4. Elston, R. C., 1985, Polymorphic markers and their use in genetic linkage, in “Biomarkers, Genetics and Cancer,” H. Anton-Guirgis and H. T. Lynch, eds., Van Nostrand Rheinold Co., New York.Google Scholar
  5. Elston, R. C., 1986, Modern methods of segregation analysis, in “Modern Statistical Methods in Chronic Disease Epidemiology,” S. H. Moolgavkar and R. L. Prentice, eds., John Wiley and Sons.Google Scholar
  6. Elston, R. C., 1987, Linkage methods for detection of major genes, paper presented at the international symposium on “Advances in Statistical Methods for Genetic Improvement of Livestock,” Armidale, Australia, Feb. 17–20.Google Scholar
  7. Elston, R. C., Kringlen, E., and Namboodiri, K. K., 1973, Possible linkage relationships between certain blood groups and schizophrenia or other psychoses, Behav. Genet., 3:101–106.PubMedCrossRefGoogle Scholar
  8. Haseman, J. K. and Elston, R. C., 1972, The investigation of linkage between a quantitative trait and a marker locus, Behav Genet., 2:3.PubMedCrossRefGoogle Scholar
  9. Holm, S., 1979, A simple sequentially rejective multiple test procedure, Scand. J. Statist., 6:65.Google Scholar
  10. Kempthorne, O., 1978, Logical, epistemological and statistical aspects of nature-nurture data interpretation, Biometrics, 34:1.PubMedCrossRefGoogle Scholar
  11. Li, C. C., 1955, “Population Genetics,” University of Chicago Press, Chicago.Google Scholar
  12. Ott, J., 1985, “Analysis of Human Genetic Linkage,” The Johns Hopkins University Press, Baltimore.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Robert C. Elston
    • 1
  1. 1.Department of Biometry and GeneticsLouisiana State University Medical CenterNew OrleansUSA

Personalised recommendations