Modification of Radiation Injury of Murine Intestinal Clonogenic Cells and B-16 Melanoma by PGI2 or Flurbiprofen

  • W. R. Hanson
  • W. Jarnagin
  • K. DeLaurentiis
  • F. D. Malkinson


Prostaglandins (PC
s) protect several types of cells in vivo from ionizing radiation. Many human tumors secrete excessive PG’s, which may result in some degree of tumor protection from radiation treatment. In contrast, PG-blocking agents might sensitize tumors to radiation. To assess a possible role of PG’s and PG-blocking agents in modifying normal tissue or tumor radiation sensitivity, either PGI2 (the most protective natural PG found to date) or Flurbiprofen (a cyclooxygenase inhibitor) was given to mice before irradiation with cesium-137. The effects of these agents on the radiosensitivity of intestinal clonogenic cells or a B-16 melanoma were measured. PGI2 increased the D° of intestinal clonogenic cell survival from about 1.15 ± 0.13 Gy in controls to 1.45 ± 0.15 Gy. Flurbiprofen had no effect on the intestinal clonogenic cell survival curve. PGI2 also protected the B-16 melanoma, but Flurbiprofen protected the melanoma to an even greater extent, mainly through an increase in the shoulder. Flurbiprofen may switch the arachidonic acid cascade to other pathways such as the 5-lipoxygenase pathway, and leukotrienes have also been shown to protect from radiation. Tumor radiosensitization may occur only through blocking all pathways of the cascade or by blocking tumor receptor sites.


Melanoma Cell Radiation Injury Murine Bone Marrow Arachidonic Acid Cascade Lung Coloni 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • W. R. Hanson
    • 1
    • 2
  • W. Jarnagin
    • 1
  • K. DeLaurentiis
    • 1
  • F. D. Malkinson
    • 2
  1. 1.Department of Therapeutic RadiologyRush-Presbyterian St. Luke’s Medical CenterChicagoUSA
  2. 2.Department of DermatologyRush-Presbyterian St. Luke’s Medical CenterChicagoUSA

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