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Changes in Renal Blood Flow, Glomerular Filtration, and Vasoactive Hormones in Bone-Marrow-Transplant Recipients After Total-Body Irradiation

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Prostaglandin and Lipid Metabolism in Radiation Injury

Abstract

Although the potential for radiation to produce renal damage at high doses has been well established, there are a few data regarding early functional and hormonal changes in the normal human kidney exposed to “tolerable dose” levels. We measured renal blood flow, glomerular filtration rate (GFR), plasma renin activity, and 6-keto-PGF1α in patients undergoing fractionated total-body irradiation (1320 rads, 13.2 Gy) prior to allogeneic bone marrow transplantation. Both renal plasma flow and GFR rose (23.8% and 28.4%, respectively), while renal vascular resistance fell. GFR rose to levels well above normal, associated with a fall in serum creatinine. These changes were accompanied by a rise in plasma renin activity and urinary 6-keto-PGF1α. We propose that irradiation at these doses induces mild renal vascular injury, allowing net vasodilation and hyperfiltration to occur. Such changes represent a hitherto-unrecognized response to whole-body irradiation.

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References

  1. Luxton, R. W., and Kunkler, P. B. Radiation nephritis. Acta Radiol. Ther. Phys. Biol. 2: 169–177, 1964.

    CAS  Google Scholar 

  2. Rosen, S., Swerdlow, M. A., Muehrcke, R. C., and Pirani, C. Radiation nephritis: Light and electron microscopic observations. Am. J. Clin. Pathol. 41: 487–502, 1964.

    PubMed  CAS  Google Scholar 

  3. White, D. C. The histopathologic basis for functional decrements in late radiation injury in diverse organs. Cancer 37: 1126–1143, 1976.

    Article  PubMed  CAS  Google Scholar 

  4. Jaenke, R. S., Phemister, R. D., and Norrdin, R. W. Progressive glomerulosclerosis and renal failure following perinatal gamma radiation in the beagle. Lab. Invest. 42: 643–655, 1980.

    PubMed  CAS  Google Scholar 

  5. Blake, D. B. Radiobiologic aspects of kidney. Radiol. Clin. North Am. 3: 75–87, 1965.

    CAS  Google Scholar 

  6. Terragno, N. A., Terragno, A., and McGiff, J. A. Contribution of prostaglandins to the renal circulation in conscious, anesthetized and laparotomized dogs. Circ. Res. 40: 590–595, 1977.

    PubMed  CAS  Google Scholar 

  7. Henrich, W. L., Anderson, R. J., and Berenes, A. S. The role of renal nerves and prostaglandins in control of renal hemodynamics and plasma renin activity during hypotensive hemorrhage in the dog. J. Clin. Invest. 61: 744–750, 1978.

    Article  PubMed  CAS  Google Scholar 

  8. Edwards, R. M. Effects of prostaglandins on vasoconstrictor action in isolated renal arterioles. Am. J. Physiol. 248: F779–784, 1985.

    PubMed  CAS  Google Scholar 

  9. Forman, S. J., Spruce, W. E., Farbstein, M. J., et al. Bone marrow ablation followed by allogeneic marrow grafting during first complete remission of acute nonlymphocytic leukemia. Blood 61: 439–442, 1983.

    PubMed  CAS  Google Scholar 

  10. Bravo, E. L., Tarazi, R. C., Fouad, F. M., Textor, S. C., Gifford, R. W., and Vidt, D. G. Blood pressure regulation in pheochromocytoma. Hypertension (Supp II) 4(3): II193–II199, 1982.

    Google Scholar 

  11. Powell, S. C., Scaro, J., Wilson, E., and Shihabi, Z. K. Assay of urinary n-acetyl-beta-glucosaminidase in a centrifugal analyzer. Clin. Chem. 29: 1717–1719, 1983.

    PubMed  CAS  Google Scholar 

  12. Zipser, R. D., Morrison, A., Laffi, J., and Duke, R. Assay methods for 6-keto-prostaglandin-F-1-alpha in human urine: Comparison of chromatographic techniques with radioimmunoassay and gas chromatography-negative-ion-space-chemical-ionization-mass-spectrometry. J. Chromatogr. 339: 1–9, 1985.

    Article  PubMed  CAS  Google Scholar 

  13. Miller, R. G. “Simultaneous Statistical Inference.” 2nd ed. Springer-Verlag, New York, 1981.

    Book  Google Scholar 

  14. Keane, W. F., Crosson, J. T., Staley, N. A., Anderson, W. R., and Shapiro, F. L. Radiation-induced renal disease. Am. J. Med. 60: 127–137, 1976.

    Article  PubMed  CAS  Google Scholar 

  15. Scanlon, G. T. Vascular alteration in the irradiated rabbit kidney. Radiology 94: 401–406, 1970.

    PubMed  CAS  Google Scholar 

  16. Donlon, M., Steel, L., Helgeson E. A., Shipp, A., and Catravas, G. N. Radiation-induced alterations in prostaglandin excretion in the rat. Life Sci. 32: 2631–2639, 1983.

    Article  PubMed  CAS  Google Scholar 

  17. Dunn, M. J. Renal prostaglandins. In: “Contemporary Nephrology.” S. Klahr and S. G. Massry, eds. Plenum Press, New York, 1983, pp. 145–191.

    Google Scholar 

  18. Belch, J. J., McLaren, M., Anderson, J., Lowe, G. D., Sturrock, R. D., Capell, H. A., Forbes, C. D., Mikhailidis, D. P., Jeremy, J. Y., and Dandona, P. Increased prostacyclin metabolites and decreased red cell deformability in patients with systemic sclerosis and Raynaud’s syndrome. Prostaglandins Leukotrienes Med. 18: 401–402, 1985.

    Article  CAS  Google Scholar 

  19. Lifschitz, M. D., and Basrnes, J. L. Prostaglandin 12 attenuates ischemic acute renal failure in the rat. Am. J. Physiol. 247: F714–717, 1984.

    PubMed  CAS  Google Scholar 

  20. Davies, D. J., Brewer, D. B., and Hardwicke J. Urinary proteins and glomerular morphometry in protein overload proteinuria. Lab. Invest. 38: 232–243, 1978.

    PubMed  CAS  Google Scholar 

  21. Bosh, J. P., Saccaggi, A., Lauer, A., Ronco, C., Belledonne, M., and Glabman, S. Renal functional reserve in humans: Effect of protein intake on glomerular filtration rate. Am. J. Med. 75: 943–950, 1983.

    Article  Google Scholar 

  22. Goodwin, C. W., Aulick, L. H., Becker, R. A., and Wilmore, D. W. Increased renal perfusion and kidney size in convalescent burn patients. JAMA 244: 1588–1590, 1980.

    Article  PubMed  CAS  Google Scholar 

  23. Mogensen, C. E., and Andersen, M. J. F. Increased kidney size and glomerular filtration rate in early juvenile diabetes. Diabetes 22: 706, 1973.

    PubMed  CAS  Google Scholar 

  24. Hostetter, T. H. “Diabetic Nephropathy in the Kidney.” B. M. Brenner and F. C. Rector, eds. W. B. Saunders, Philadelphia, 1986, pp. 1377–1402.

    Google Scholar 

  25. Lindheimer, M. D., and Katz, A. I. The kidney in pregnancy. In: “The Kidney.” B. M. Brenner and F. C. Rector, eds. W. B. Saunders, Philadelphia, 1986, pp. 1253–1295.

    Google Scholar 

  26. Baylis, C. The mechanism of the increase in glomerular filtration rate in the twelve-day pregnant rat. J. Physiol. 305: 405, 1980.

    PubMed  CAS  Google Scholar 

  27. Conrad, K. P. Renal hemodynamics during pregnancy in chronically catheterized conscious rats. Kidney Int. 26: 24, 1984.

    Article  PubMed  CAS  Google Scholar 

  28. Fisher, E. R., and Hellstrom, H. R. Pathogenesis of hypertension and pathologic changes in experimental renal irradiation. Lab. Invest. 19: 530–538, 1968.

    PubMed  CAS  Google Scholar 

  29. Ljungqvist, A., Unge, G., Lagergren, C., and Notter, G. The intrarenal vascular alterations in radiation nephritis and their relationship to the development of hypertension. Acta Path. Microbiol. Scand. Section A 79: 629–638, 1971.

    CAS  Google Scholar 

  30. Textor, S. C., Forman, S. J., Borer, W. Z., and Carlson, J. Sequential blood pressure, hormonal and renal changes during cyclosporine administration in bone marrow transplant recipients with normal renal function. Clin. Res. 34: 487 A, 1986.

    Google Scholar 

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Authors and Affiliations

  1. Department of Consultative Medicine/Nephrology, City of Hope National Medical Center, Duarte, California, 91010, USA

    S. C. Textor & J. E. Carlson

  2. Department of Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, California, 91010, USA

    S. J. Forman

  3. Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA

    R. D. Zipser

Authors
  1. S. C. Textor
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  2. S. J. Forman
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  3. R. D. Zipser
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  4. J. E. Carlson
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Editor information

Editors and Affiliations

  1. Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA

    Thomas L. Walden Jr.  & Haywood N. Hughes  & 

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© 1987 Plenum Press, New York

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Textor, S.C., Forman, S.J., Zipser, R.D., Carlson, J.E. (1987). Changes in Renal Blood Flow, Glomerular Filtration, and Vasoactive Hormones in Bone-Marrow-Transplant Recipients After Total-Body Irradiation. In: Walden, T.L., Hughes, H.N. (eds) Prostaglandin and Lipid Metabolism in Radiation Injury. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5457-4_32

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  • DOI: https://doi.org/10.1007/978-1-4684-5457-4_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5459-8

  • Online ISBN: 978-1-4684-5457-4

  • eBook Packages: Springer Book Archive

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