A Paradoxical Role for Eicosanoids: Radioprotectants and Radiosensitizers

  • T. L. WaldenJr.


Understanding the radiobiology of eicosanoids is complicated by their ability to act as mediators of damage and recovery and as radioprotective agents. Changes in the tissue concentrations of eicosanoids following irradiation are dependent on several factors, including the type of eicosanoid, time postirradiation, radiation dose, and other contributing mediators and enzyme changes in the surrounding microenvironment. Many of these same prostaglandins and the leukotrienes have been shown to be radioprotective when given before irradiation.


Arachidonic Acid Radiation Injury Hydroxy Fatty Acid Arachidonic Acid Cascade Free Arachidonic Acid 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • T. L. WaldenJr.
    • 1
  1. 1.Department of Radiation BiochemistryArmed Forces Radiobiology Research InstituteBethesdaUSA

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