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Alterations in Locomotor Activity Induced by Radioprotective Doses of 16,16-Dimethyl Prostaglandin E2

  • M. R. Landauer
  • T. L. Walden
  • H. D. Davis
  • J. A. Dominitz

Abstract

16, 16-Dimethyl prostaglandin E2 (DiPGE2) is an effective radioprotectant when administered before irradiation. A notable side effect of this compound is sedation. In separate experiments, we investigated the dose-response determinations of the time course of locomotor activity and 30-day survival after 10 Gy gamma irradiation (LD100). Adult male CD2F1 mice were injected subcutaneously with vehicle or DiPGE2 in doses ranging from 0.01 to 40 μg/mouse. A dose of 0.01 μg did not result in alterations in locomotor behavior or enhance survival. Doses greater than 1 μg produced ataxia and enhanced radiation survival in a dose-dependent fashion. Full recovery of locomotor activity did not occur until 6 and 30 hr after injection for the 10 μg and 40-μg groups, respectively. Radioprotection was observed when DiPGE2 was administered preirradiation but not postirradiation. Doses of 1 and 10 μg were maximally effective as a radioprotectant if injected 5 min prior to irradiation (80%–90% survival). A dose of 40 μg resulted in 100% survival when injected 5–30 min before irradiation. Therefore, increasing doses of DiPGE2 resulted in enhanced effectiveness as a radioprotectant. However, the doses that were the most radioprotective were also the most debilitating to the animal.

Keywords

Locomotor Activity Locomotor Behavior Vehicle Control Group Mental Alertness Radioprotective Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. R. Landauer
    • 1
  • T. L. Walden
    • 2
  • H. D. Davis
    • 1
  • J. A. Dominitz
    • 1
  1. 1.Behavioral Sciences DepartmentArmed Forces Radiobiology Research InstituteBethesdaUSA
  2. 2.Radiation Biochemistry DepartmentArmed Forces Radiobiology Research InstituteBethesdaUSA

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