Effects of Neutron Irradiation on PGE2 and TxB2 Levels in Biological Fluids: Modification by WR-2721

  • L. K. Steel
  • G. D. Ledney


Whole-body fission neutron irradiation of mice results in changes in plasma and urinary prostaglandin levels. No relationship was found between urinary TxB2 excretion and the neutron dose. Elevated plasma PGE2 at 2–4 days postexposure coincides with increased PGE2 in the urine. A second increase in urinary PGE2 occurred 6–10 days postirradiation, and was dose dependent up to 3.85 Gy. Plasma PGE2 levels at this time were normal. WR-2721 administration markedly increased (24 hr) and then reduced (2–4 days) PGE2 excretion in nonirradiated animals. The urinary PGE2 of WR-2721-pretreated, irradiated mice paralleled those of drugtreated, nonirradiated animals for the first 5 days. However, WR-2721 injection did not modify the elevation of PGE2 occurring 6–10 days postexposure. Urinary TxB2 from nonirradiated groups was not altered by WR-2721, but the combination of drug and radiation resulted in increased levels 1–7 days postexposure. These results further implicate prostaglandins in the biological response to radiation exposure and suggest another mechanism of WR-2721 radioprotection.


PGE2 Level Fission Neutron Prostaglandin Release TxB2 Level Urinary PGE2 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • L. K. Steel
    • 1
  • G. D. Ledney
    • 2
  1. 1.Department of Radiation BiochemistryArmed Forces Radiobiology Research InstituteBethesdaUSA
  2. 2.Department of Experimental HematologyArmed Forces Radiobiology Research InstituteBethesdaUSA

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