Hippuric Acid as a Marker
There are some classical markers of uremic solute retention, such as serum urea and creatinine concentration. These parameters are however not always reliable, especially not in dialysis patients, so that it seemed interesting to us to undertake a multifactorial study, in an attempt to define the most suitable marker molecules in uremia. For this purpose, we used high performance liquid chromatography HPLC as a basic technique.
KeywordsToxicity HPLC Urea Creatinine Toluene
Unable to display preview. Download preview PDF.
- 1.A. Schoots, H. Homan, R. De Smet, C. Cramers, R. Vanholder and S. Ringoir: Evaluation of in vivo dialysis efficiency in hemodialysis and hemodiafiltration by reversed-phase liquid chromatography. In: First international symposium on single-needle dialysis. Ed. S. Ringoir, R. Vanholder, P. Ivanovich, ISAO Press, Cleveland (1984) p. 151.Google Scholar
- 2.A. Schoots, R. Vanholder, M. Gladdines, R- De Smet, C. Cramers and S. Ringoir: Hippuric acid and an unidentified compound as possible indicators of residual renal function in dialysed patients. In: Immune and Metabolic Aspects of Therapeutic Blood Purification Systems. Ed.: L.C. Smeby, S. Jorstad, I.E. Wideroe, Karger, Basel (1985) p. 240.Google Scholar
- 3.M.D. Armstrong, F.C. Chao, V.J. Parker and P. E. Wall: Endogenous formation of hippuric acid. Proc. Soc. Exper. Biol. & Med. 90: 675 (1955).Google Scholar
- 5.E. Bourke, G. Frindt, H. Preuss, E. Rose, M. Weksler and G.E. Schreiner: Studies with uraemic serum on the renal transport of hippurates and tetraethylammonium in the rabbit and rat: effects of oral neomycin. Clin. Science, 38: 41 (1970).Google Scholar