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Polyamines and Uremia

  • Robert A. Campbell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 223)

Abstract

In 1678, Antony Van Leeuwenhoek described the deposition of colorless crystals, later to be identified as spermine (SPM) phosphate, in seminal fluid. SPM is one of the aliphatic cations called polyamines (PAs) found in all living things. (See Table 1) The diamine putrescine (PTC) proved to be an essential growth factor for mutant Hemophilus parainfluenza. In mammals, increased biosynthesis of PAs, including spermidine (SPD), was detected during both normal and pathological tissue growth. Increased amount of SPM, SPD, and PTC were found in blood and urine under these circumstances. The nature and regulatory functions of PAs and the enzymes controlling their production and metabolic degradation are beginning to be understood.

Keywords

Arterial Smooth Muscle Cell Renal Hypertrophy Diamine Oxidase Activity Uremic Serum Uremic Plasma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Robert A. Campbell
    • 1
  1. 1.Department of PediatricsOregon Health Sciences UniversityPortlandUSA

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