Polyamines and Uremia
In 1678, Antony Van Leeuwenhoek described the deposition of colorless crystals, later to be identified as spermine (SPM) phosphate, in seminal fluid. SPM is one of the aliphatic cations called polyamines (PAs) found in all living things. (See Table 1) The diamine putrescine (PTC) proved to be an essential growth factor for mutant Hemophilus parainfluenza. In mammals, increased biosynthesis of PAs, including spermidine (SPD), was detected during both normal and pathological tissue growth. Increased amount of SPM, SPD, and PTC were found in blood and urine under these circumstances. The nature and regulatory functions of PAs and the enzymes controlling their production and metabolic degradation are beginning to be understood.
KeywordsArterial Smooth Muscle Cell Renal Hypertrophy Diamine Oxidase Activity Uremic Serum Uremic Plasma
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