Hemofiltration-Induced Serum Modifications in the Pattern of Larger Molecules
In early clinical trials, hemofiltration (HF),unlike standard dialysis (HD), seemed able to improve some uremic abnormalities, such as neurophathy(1), lipid metabolism(2)and osteopathy(3). These results could have been the consequence of better removal of high molecular weight uremic toxins,according to the “Middle Molecules” hypothesis(4). However, in subsequent long-term studies, these observations were not univocally confirmed(5), and HF has not proved to be a more efficient treatment of the uremic syndrome than HD.
KeywordsEarly Clinical Trial Lower Molecular Weight Substance Peripheral Nerve Function Body Pool Metabolic Advantage
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