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Uremic Toxins pp 281-286 | Cite as

Hemofiltration-Induced Serum Modifications in the Pattern of Larger Molecules

  • S. David
  • R. Barani
  • C. Buzio
  • L. Arisi
  • P. Quaretti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 223)

Abstract

In early clinical trials, hemofiltration (HF),unlike standard dialysis (HD), seemed able to improve some uremic abnormalities, such as neurophathy(1), lipid metabolism(2)and osteopathy(3). These results could have been the consequence of better removal of high molecular weight uremic toxins,according to the “Middle Molecules” hypothesis(4). However, in subsequent long-term studies, these observations were not univocally confirmed(5), and HF has not proved to be a more efficient treatment of the uremic syndrome than HD.

Keywords

Early Clinical Trial Lower Molecular Weight Substance Peripheral Nerve Function Body Pool Metabolic Advantage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Beckmann H.,Ossenkop C.,Quellhorst E., Changes in peripheral nerve function with long-term hemofiltration. J.Dialysis, 1:585 (1977)Google Scholar
  2. 2.
    Henning H.V.,Balusek E., Lipid metabolism in uremia:effect of regular hemofiltration and hemodialysis treatment.J. Dialysis, 1(6):595 (1977).Google Scholar
  3. 3.
    Schultz,W, Baier E., Humpfner A., Delling G., Clinical problems of renal osteopathy in patients on hemofiltration. Contr.Nephrol., 32:86 (1982).Google Scholar
  4. 4.
    Babb A.L., Farrell P.C.,Uvelli D.,A., Scribner B.H., Hemodialyzer evaluation by examination of solute molecular weight spectra: Implications for the square-meter-hour hypothesis. Trans.ASAIO 18:98 (1972).CrossRefGoogle Scholar
  5. 5.
    Koch K.M.,Prospects of hemofiltration, Int. J.Artif.Organs 1:5 (1983)Google Scholar
  6. 6.
    David S.,Ferrari M.E., Arisi L,Cambi V.,Effects of high efficiency hemofiltration on glucose and nitrogen metabolism Blood Purif. 2:4 (1984)Google Scholar
  7. 7.
    Minetti I., Civati G., Guastoni C., Perego A.,Teatini U., Minimal standards for hemofiltration, Kidney Int. 28(17): S-116 (1985).Google Scholar
  8. 8.
    Buzio C.,Montagna G., Calderini M.C., Manari A.,Migone L., Methodology for identification of serum Middle Molecules. Artif. Organs 4(s):23 (1980)Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • S. David
    • 1
  • R. Barani
    • 1
  • C. Buzio
    • 1
  • L. Arisi
    • 1
  • P. Quaretti
    • 1
  1. 1.Clinical Medicine and Nephrology Dept.University of ParmaParmaItaly

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