Isolation of Sialylcompounds from Hemofiltrate of Chronic Uremic Patients and Identification by Nuclear Magnetic Resonance
Sialylcompounds in the molecular weight range between 500 and 2000 D (sialyloligosaccharides, -glycopeptides) are structurally related to the carbohydrate components of serum- and tissue glycoconjugates, which are involved in numerous biological processes1. Many of them occur in cow colostrum, human milk and urine; structures and amount of excreted compounds vary under different physiological and pathological conditions. In serum they are usually not detectable. Since they are proposed to originate from biosynthesis and degradation of sialoglycoconjugates, their identification in uremic body fluids may contribute to a better knowledge of their metabolism.
KeywordsSialic Acid Molecular Weight Range Polysialic Acid Neuraminic Acid Peritoneal Dialysis Fluid
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