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Uremic Toxins pp 219-222 | Cite as

Isolation of Sialylcompounds from Hemofiltrate of Chronic Uremic Patients and Identification by Nuclear Magnetic Resonance

  • Gerhard Weißhaar
  • Helmut Brunner
  • Horst Friebolin
  • Wolfgang Baumann
  • Helmut Mann
  • Hans-Jesef Opferkuch
  • Heinz-Günther Sieberth
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 223)

Abstract

Sialylcompounds in the molecular weight range between 500 and 2000 D (sialyloligosaccharides, -glycopeptides) are structurally related to the carbohydrate components of serum- and tissue glycoconjugates, which are involved in numerous biological processes1. Many of them occur in cow colostrum, human milk and urine; structures and amount of excreted compounds vary under different physiological and pathological conditions. In serum they are usually not detectable. Since they are proposed to originate from biosynthesis and degradation of sialoglycoconjugates, their identification in uremic body fluids may contribute to a better knowledge of their metabolism.

Keywords

Sialic Acid Molecular Weight Range Polysialic Acid Neuraminic Acid Peritoneal Dialysis Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Gerhard Weißhaar
    • 1
  • Helmut Brunner
    • 2
  • Horst Friebolin
    • 1
  • Wolfgang Baumann
    • 1
  • Helmut Mann
    • 2
  • Hans-Jesef Opferkuch
    • 3
  • Heinz-Günther Sieberth
    • 2
  1. 1.Organisch-Chem. Institut der Unversität HeidelbergHeidelbergGermany
  2. 2.Abteilung Innere Medizin II der R.W.T.H. Aachen PauwelsstrAachenGermany
  3. 3.Zentrale Arbeitsgruppe SpektroskopieDeutsches KrebsforschungszentrumHeidelbergGermany

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