Middle Molecules and the 7 C Factor
Soon after Babb and Scribner in 19721 presented The Middle Molecule Hypothesis several investigators performed clinical studies in dialysis patients, designed to increase or decrease the presumed level of middle molecules (MM) in the body fluids relating these changes to the symptomatology of the patients or to the in vitro toxicity of plasma and dialysate (see references in 1). However, most of these studies were inconclusive and no direct determination of MM were performed.
KeywordsHigh Performance Liquid Chromatography Salicylic Acid Continuous Ambulatory Peritoneal Dialysis Reverse Phase High Performance Liquid Chromatography Uremic Patient
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