Uremic Toxins pp 189-192 | Cite as

Conversion of Ammonia to Glutamate by L-Glutamic Dehydrogenase, Alcohol Dehydrogenase and NAD+ Immobilized within Lipid-Polyamide Polyethyleneimine Microcapsules

  • Ehud Ilan
  • Thomas Ming Swi Chang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 223)


The use of Albumin-Collodion coated Activated Charcoal (ACAC) hemoperfusion systems for treatment of end-stage renal failure has several advantages over the hemodialysis procedure. With coated charcoal ACAC hemoperfusion, the removal of uremic toxins, such as creatinine, uric acid, and middle molecules, is much more effective than with standard hemodialysis. However, the ACAC hemoperfusion system does not remove water, electrolytes or urea. As the removal of excess water can be achieved with the help of a small ultrafiltrator1,2, the remaining major problems are electrolytes and urea removal.


Alcohol Dehydrogenase Uremic Toxin Artificial Cell Polyamide Membrane Middle Molecule 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Ehud Ilan
    • 1
  • Thomas Ming Swi Chang
    • 1
  1. 1.Artificial Cells and Organs Research Centre, Faculty of MedicineMcGill UniversityCanada

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