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Uremic Toxins pp 157-160 | Cite as

The Immunosuppressive Fraction Isolated from Uremic Ultrafiltrates: Attempted Characterization of the Mechanism of Action

  • J. Navarro
  • M. C. Grossetête
  • J. L. Touraine
  • J. Traeger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 223)

Abstract

Since many years our attention has been focused on the isolation of an immunosuppressive fraction from the serum of uremic patients. This fraction which was obtained after a single chromatography of uremic fluids on a Sephadex. G25 column, was shown to inhibit markedly the lymphocyte proliferation induced by several mitogens and by allogeneic cells. A continuous infusion of this material in rats allowed a significant prolongation of skin allograft survival. By contrast the antibody production to sheep red blood cells was not affected by such a treatment. Furthermore, this crude fraction reduced significantly the graft-versus-host reaction induced in lethally irradiated mice injected with allogeneic spleen lymphocytes previously incubated in the presence of the uremic factor. Inhibition of cell proliferation appears to be the common denominator of all these in vitro and in vivo immunosuppressive effects.

Keywords

Allogeneic Cell Crude Fraction Uremic Solute Skin Allograft Survival Rative Spleen Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. Navarro
    • 1
  • M. C. Grossetête
    • 1
  • J. L. Touraine
    • 1
  • J. Traeger
    • 1
  1. 1.Inserm U.80, CNRS UA 1177UCBLyonFrance

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