Skip to main content
SpringerLink
Log in
Book cover

Uremic Toxins pp 149–152Cite as

Does Hypermagnesemia Suppress Parathyroid Activity and Therefore Play a Role in Amelioration of Uremic Toxicity ?

  • Chapter

  • 73 Accesses

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 223))

Abstract

Parathyroid hormone satisfies all criteria of a uremic toxin, due to a cause and effect relationship between excess parathyroid hormone and disturbances of the nervous system in uremia1. Reports concerning the suppression of parathyroid activity by hypermagnesemia are few and contradictory2,3 Therefore, the long-term administration of magnesium hydroxide (Mg(OH)2) as phosphate binder in patients on hemodialysis was an excellent opportunity for an own observation of the relationship between hypermagnesemia and parathyroid activity.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. S. G. Massry, Neurotoxicity of parathyroid hormone in uremia, Kidn. Intern. 28;suppl. 17 S-5 (1985).

    Google Scholar 

  2. S. G. Massry, J. W. Coburn, and C. R. Kleeman, Evidence for suppression of parathyroid gland activity by hypermagnesemia, J. Clin. Invest. 49:1619 (1979).

    Article  Google Scholar 

  3. M. Gonella, L. Moriconi, G. Betti, F. Bonaguidi, G. Buzzigoli, V. Bartolini, and G. Mariani, Serum levels of PTH, Mg, Ca, inorganic phosphate and alkaline phosphatase in uraemic patients on differentiated Mg dialysis, Proc. EDTA 17:362 (1980).

    CAS  Google Scholar 

  4. A. W. Landall, J. Elting, J. Ells, and B. A. Roos, Estimation of biologically active intact parathyroid hormone in normal and hyper- parathyroid sera, J. Clin. End. Metab. 57:1007 (1983).

    Article  Google Scholar 

  5. G. B. v.d. Voet, E. J. M. de Haas, and F. A. de Wolf, Monitoring of aluminum in whole blood, plasma, serum and water, J. Anal. Tox. 9:97 (1985).

    Google Scholar 

  6. R. E. Randall, D. Cohen, C. C. Spray, and E. C. Rossmeisl, Hypermagne semia in renal failure, Ann. Intern. Med. 61:73 (1964).

    PubMed  CAS  Google Scholar 

  7. A. P. Guillot, V. L. Hood, C. F. Runge, and F. J. Gennari, The use of magnesium-containing phosphate binders in patients with end-stage renal disease on maintenance hemodialysis. Nephron 30:114 (1982).

    Article  PubMed  CAS  Google Scholar 

  8. 8.F. P. Brunner, and G. Thiel, The use of magnesium-containing phosphate binders in patients with end-stage renal disease on maintenance haemodialysis, Nephron 32:266 (1982).

    Article  PubMed  CAS  Google Scholar 

  9. J. v.d. Meulen, P. D. Bezemer, P. Lips, and P. L. Oe, Individual differences in gastrointestinal absorption of aluminum, N. Engl. J. Med. 311:1322 (1984).

    Article  PubMed  Google Scholar 

  10. R. O’Donovan, C. Monitz, D. Baldwin, M. Rogerson, and V. Parsons, Hyperfosfataemia is controlled by oral magnesium carbonate while on zero magnesium dialysate without aluminium binders, Proc. EDTA-ERA 22:1229 (1985).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Academic Hospital Free University, de Boelelaan 1117, 1081, HV Amsterdam, The Netherlands

    P. L. Oe, J. van der Meulen, P. T. A. M. Lips, P. M. J. M. de Vries, H. van Bronswijk & A. J. M. Donker

Authors
  1. P. L. Oe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. van der Meulen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. T. A. M. Lips
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. M. J. M. de Vries
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. van Bronswijk
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. J. M. Donker
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Ghent, Ghent, Belgium

    Severin Ringoir  & Raymond Vanholder  & 

  2. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Press, New York

About this chapter

Cite this chapter

Oe, P.L., van der Meulen, J., Lips, P.T.A.M., de Vries, P.M.J.M., van Bronswijk, H., Donker, A.J.M. (1987). Does Hypermagnesemia Suppress Parathyroid Activity and Therefore Play a Role in Amelioration of Uremic Toxicity ?. In: Ringoir, S., Vanholder, R., Massry, S.G. (eds) Uremic Toxins. Advances in Experimental Medicine and Biology, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5445-1_23

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5445-1_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5447-5

  • Online ISBN: 978-1-4684-5445-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation