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Uremic Toxins pp 119-123 | Cite as

A Possible Regulatory System of Microtubule Formation Among Uremic Toxins

  • Diane Braguer
  • Philippe Gallice
  • Jean-Pierre Monti
  • Claude Durand
  • Antoine Murisasco
  • Aimé Crevat
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 223)

Abstract

Tubulin is an intracellular protein, whose polymerization leads to the formation of microtubules (MT). MT are an essential component of axons of nerve cells, and the rate of axon regeneration depends on the synthesis or polymerization of tubulin 1. Uremic plasma inhibits the growth of nervous fibers in chicken embryo. Moreover, in uremic neuropathy, axonal degeneration is frequently observed 2. Thus, in uremic patients, MT formation from tubulin polymerization may be inhibited. If this effect also occurs in vivo, uremic toxins (UT) might be involved in the pathogenesis of uremic neuropathy.

Keywords

Renal Transplant Recipient Chicken Embryo Axon Regeneration Axonal Degeneration Nervous Conduction Velocity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Diane Braguer
    • 1
  • Philippe Gallice
    • 1
  • Jean-Pierre Monti
    • 1
  • Claude Durand
    • 2
  • Antoine Murisasco
    • 2
  • Aimé Crevat
    • 1
  1. 1.Laboratoire de Biophysique, Faculté de PharmcieMarseille Cedex 5France
  2. 2.Service de NéphrologieHôpital Sainte-MargueriteMarseilleFrance

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