Uremic Toxins pp 105-109 | Cite as

Pathogenesis and Consequences of the Alteration of Glucose Metabolism in Renal Insufficiency

  • Rastislav Dzúrik
  • Viera Spustová
  • Mária Geryková
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 223)


The decreased hyperglycemic response of patients in renal insufficiency (RI) to the applied glucagon or epinephrine and abnormal galactose tolerance test pointed to the abnormal liver glycogen metabolism and its decreased liver concentration (Cohen, 1962; Westervelt and Schreiner, 1962). However, later on the glucagon and epinephrine studies have not been confirmed and normal liver glycogen concentration was found in a group of patients with normal caloric intakte in our laboratory (Dzúrik and Brixová, 1968). The liver glycogen concentration was normal even in patients with abnormal glucose tolerance test. Similar findings were published on muscle glycogen by Bergström (Bergström and Hultman, 1969). It appears now that the glycogen concentration and metabolism depend primarily on nutritional state and not on renal insufficiency. Consequently, adequate caloric intake is the best prevention of this abnormality.


Glucose Utilization Kidney Cortex Hyperglycemic Response Fasting Hypoglycemia Uremic Serum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bergström, J., and Hultman, H., 1969, Glycogen contet of skeletal muscle in patients with renal failure. Acta Med Scand., 186:177.PubMedCrossRefGoogle Scholar
  2. Cohen, B. D., 1962, Abnormal carbohydrate metabolism in renal disease, Ann Int Med., 57:204.PubMedGoogle Scholar
  3. De Fronzo, R. A., Smith, D., and Alvestrand, A., 1983, Insulin action in uremia. Kidney Int., 16:S102.Google Scholar
  4. Dzúrik, R., and Brixová, E., 1968, Liver glycogen concentration in patients with chronic uremia, Experientia, 24:352.CrossRefGoogle Scholar
  5. Dzúrik, R., Hupková, V., Černáček, P., Valovičová, E., and Niederland, T. R., 1973, The isolation of an inhibitor of glucose utilization from the serum of uremic subjects, Clin Chim Acta, 46:77.PubMedCrossRefGoogle Scholar
  6. Dzúrik, R., Spustová, V., and Černáček, P., 1980, Inhibitor of renal gluconeogenesis (IGN): Additional physiological modulator?, Int J Biochem, 12:103.PubMedCrossRefGoogle Scholar
  7. Dzúrik, R., and Spustová, V., 1984, Pathogenesis of the metabolic alterations in renal insufficiency. Rev Czech Med., 7:207.Google Scholar
  8. Lamberts, B., Brunner, H., Ochs, H. G., Spellerberg, P., and Heintz, R., 1976, Effect of urine metabolites from healthy and uremic subjects on gluconeogenesis in slices of rat kidney cortex and liver, Clin Nephrol, 6:465.PubMedGoogle Scholar
  9. Mitch, W. E., and Brusilow, S., 1982, Benzoate-induced changes in glycine and urea metabolism in patients with chronic renal failure, J Pharmacol Exp Therap., 222:572.Google Scholar
  10. Westervelt, Jr., B. F., and Schreiner, G. E., 1962, The carbohydrate intolerance of uremic patients, Ann Int Med., 57:266.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Rastislav Dzúrik
    • 1
  • Viera Spustová
    • 1
  • Mária Geryková
    • 1
  1. 1.Medical Bionics Research InstituteBratislavaCzechoslovakia

Personalised recommendations